80 ANDREWS. 



bronchi present absolutely no evidence of inflammation. In the 

 anterior portions of the lungs there is more or less evidence of 

 emphysema as shown by the thinned and broken alveolar walls. 



Spleen. — The spleen shows intense congestion. In many places 

 haemorrhages have taken place in the splenic tissue as shown by 

 the almost solid mass of red cells present. There is no increase 

 of splenic tissue. 



Liver. — Besides the congestion, the other changes are slight 

 albuminous degeneration and fatty infiltration. The fatty de- 

 posit is scattered through the liver substance, but is probably 

 more prominent around the portal-spaces. In some cases con- 

 siderable haemorrhage is present beneath the capsule. 



Adrenals. — Other than congestion, they present nothing ab- 

 normal. 



Thyroid. — The sections of some cases show the presence of 

 more colloid material than do the sections of others. Congestion 

 is present. 



Parathyroids. — Aside from congestion they are apparently 

 normal. The nuclei are deeply staining and are surrounded by 

 a clear protoplasm. The cell membrane is clearly defined. 



Thymus. — In some cases there is possibly an increase of the 

 cellular elements. Hassel's corpuscles appear normal. Conges- 

 tion is present. 



Kidneys. — These organs are intensely congested. Albuminous 

 degeneration of the convoluted tubules is shown in a number 

 of the cases and a few show fatty degeneration in addition. 

 The endothelial cells of the glomeruli seem to be increased in 

 number and in many cases there is a slight granular detritus 

 in Bowman's capsule. There is no infiltration of leucocytes. 

 There is apparently no difference between the sections of the 

 kidneys in which oliguria was present and those in which it 

 was absent. It is probable that the condition of the glomeruli 

 and Bowman's capsule is due to the intense congestion present. 



Nerves. — Sections from various nerves (vagi, phrenic, inter- 

 costal, and anterior tibial) were taken for staining. These were 

 stained by Marchi's method and show degeneration of some of 

 the fibers. The degeneration is not as extensive as is found 

 in cases of adult beriberi but is clearly defined. 



EXPERIMENT ON PUPPIES. 



Since in infants sick of this disease, improvement rapidly 

 follows a change in diet, it seems evident that the mother's milk 

 bears some causal relation to the condition. The disease is 

 evidently not due to bacteria in the milk, for in that case, im- 



