BACTERIOLOGY. 



193 



Table I. — Showing virulence of various cultures of plague. 



Number 



of ffuinea 



piff. 



WeiKht 



of guinea 



piR. 



Number of 

 culture. 



Number of 



days before 



death. 





Grama. 





Days. 



6258 



400 



1 



3i 



6269 



890 



2 



4 



6261 



360 



5 



6J 



6262 



860 



7 



7i 



626S 



840 



8 



7 



6264 



400 



9 



3 



6266 



360 



10 



7 



6266 



350 



21 



6 



5267 



390 



22 



5i 



5292 



350 



16 



8 



5293 



380 



23 



6i 



5294 



390 



25 



6 



5295 



390 



26 



5 



5297 



330 



28 



3 



6298 



360 



29 



5i 



5300 



370 



31 



5i 



5326 



330 



11 



5 



5326 



350 



12 



7 



5327 



380 



13 



54 



5328 



360 



14 



10 



5329 



380 



15 



5i 



5330 



360 



17 



5 



5331 



380 



18 



4i 



5332 



370 



19 



5 



5334 



350 



Shanghai. 



(«) 



5335 



360 



Mariveles. 



54 



5336 



340 



Hongkong'. 



5 



5415 



340 



32 



9 



• Developed buboes, but recovered. 



These experiments and those already referred to (loc. cit.) 

 have shown that the pneumonic cultures have not possessed any 

 greater virulence than that possessed by many virulent bubonic 

 ones of the organism. Mice, rats, guinea pigs, and monkeys 

 inoculated with virulent bubonic cultures die within the same 

 period of time and from the same doses as do the corresponding 

 animals inoculated with the pneumonic cultures. The same 

 lesions are observed in animals after inoculation of the pneu- 

 monic strain as after the inoculation of the bubonic strain. 

 Both strains when inoculated cutaneously, or subcutaneously, 

 into guinea pigs and monkeys give rise to bubonic-plague infec- 

 tion. When the animals are infected by inhalation with either 

 strain, similar lesions are also produced. In guinea pigs, after 

 inhalation, infection results through the mucous membrane of 

 the throat and upper portion of the respiratory tract, resulting 

 in buboes of the cervical glands and septicaemia and in primary 

 or secondary pneumonia; in monkeys, after infection by inhala- 

 tion, primary pneumonic infection of the lung with secondary 

 septicaemia results. 



However, while during epidemics of bubonic plague reports 



10593fi 5 



