ETIOLOGY OF BERIBERI. 323 



sound was prolonged, but there was no distinct murmur; the 

 second sounds were not accentuated nor reduplicated at the base. 

 On the eighty-first day he was taken to the prison hospital on 

 account of the persistent dyspnoea. Here he was given the same 

 diet, and was isolated in a locked room. However, it is possible 

 that he may have received some other food during the time he was 

 in the hospital. On the eighty-fourth day the pulse was 100 and 

 the respirations 40; the heart sounds were clear; the first sound 

 was prolonged; there was no cardiac pulsation visible and no 

 distinct increase in the area of dulness to the right or left; the 

 knee jerks were doubtful; the legs were held rigidly. On the 

 eighty-fifth day he stated his fingers felt as though they were 

 made of rubber. There was slight anaesthesia over the finger 

 tips. The systolic blood pressure was 85 millimeters Hg. On 

 the eighty-eighth day the note states : Pulse 72 ; no epigastric nor 

 cardiac throbbing; no marked tenderness of calves of the legs. 

 On the eighty-ninth day, general condition very much the same; 

 the knee jerks are absent. On the ninetieth day the pulse was 

 88 ; the patient complained of pain in the legs and chest ; he was 

 very weak, but could walk ; his gait showed evidence of muscular 

 weakness, but was not typically ataxic ; there was hyperaesthesia 

 of the muscles of the legs, and there was slight oedema over the 

 tibiae; there was no epigastric nor prsecordial pulsation. The 

 knee jerks were absent. On the ninety-first to the ninety-seventh 

 days the jerks were always absent. The condition of the patient 

 remained about the same, except that he grew weaker. On the 

 ninety-seventh day there was slight oedema over the tibise. The 

 diet was then discontinued. This man evidently suffered from 

 beriberi. The urine was examined daily for the last three weeks 

 of the experiment. It was always greatly decreased in amount 

 but contained no albumin nor casts. 



CASE NO. 10 (GROUP II). 



Diet: White rice 108 days, together with the special diet common to all the 



g^roups. 

 Dried codfish and potatoes were added to the diet on the 97th day. 



Following is a summary of the notes of the case : Sparely 

 nourished man of small stature ; percussion and auscultation of 

 the lungs normal ; examination of the heart shows no increase of 

 the area of dulness beyond the normal ; the point of maximum im- 

 pulse is invisible; it is palpable 6.25 centimeters to the left of 

 the median line and 3 centimeters below the nipple line ; the heart 

 sounds are clear at the apex and base ; there is no epigastric pul- 

 sation; the pulse is 84, and the systolic blood pressure 124 milli- 



