382 STRONG AND CROWELL. 



Pancreas is of normal size, firm, pale with distinct lobular markings and 

 patent duct. 



Liver and gall bladder. — The gall bladder is small and contains a small 

 amount of golden yellow bile which is readily expressed through the ducts. 

 Common, cystic, and hepatic ducts normal. Liver is of about normal size, 

 its capsule thin, smooth, and transparent. The edges are slightly rounded 

 and the surface smooth and a deep red color with small areas of yellowish 

 mottling. On section the organ is soft and the cut surface smooth. In 

 color it is very deep red, the red masses and strands being rather prominent 

 above the surface, surrounding and including small pin-head-sized areas of 

 a much paler parenchyma. Some few small yellowish foci are seen in the 

 parenchyma. The general architecture of the cut surface is destroyed by 

 the prominence and distribution of the elevated red areas which obliterate 

 the normal markings. 



Lymphatic glands of mesentery, retroperitoneal space, and lesser sac are 

 small and pink on section. 



Brain. — Structures of scalp are oedematous. Calvarium normal. Dura 

 mater is nonadherent. Longitudinal sinus free. Inner surface of dura 

 mater smooth. There is a slight excess of clear fluid in the meshes of the 

 pia arachnoid over the hemispheres. The meningeal vessels are prominent. 

 Vessels at the base in good condition. Ventricles are not dilated and 

 ependyma is smooth. Section of brain substances shows no gross lesions. 



Sections of the viscera were preserved in Zenker's fluid and in 10-per- 

 cent formalin. Sections of the two vagi, anterior tibial, and popliteal nerves 

 were preserved in Miiller's fluid. 



HISTOLOGICAL EXAMINATION. 



Heart. — There is considerable oedema and some increase of 

 the adipose tissue beneath the epicardium and of that between 

 the muscle bundles. The muscle fibers themselves are swollen 

 and granular. When seen in longitudinal section the muscle 

 fibrils are very distinct and in many the nuclei are poor in 

 chromatin. Occasionally vacuoles are seen in the protoplasm 

 of the fibers. Each of these features is much exaggerated when 

 the bundles are seen in transverse section. The fibrils of the 

 muscles are comparatively widely separated and much more 

 readily visible than normal. Irregular vacuolated areas are 

 very frequent, and the nuclei are frequently entirely gone, being 

 replaced by a vacuole or a homogeneous mass which does not 

 take the hsemotoxylin stain. Staining with Sudan III shows 

 very little fat in the muscle fibers. No round-celled foci and 

 no marked multiplication of the nuclei are seen. 



Liver. — In the liver the cells in the immediate neighborhood 

 of the central veins are much swollen and granular with indis- 

 tinct outlines and the portal spaces have a more or less normal 

 appearance. The architecture of the entire remaining portions 

 of the liver is destroyed. In the mid-zone and periphery of the 



