ETIOLOGY OF BERIBERI. 



403 



loss of knee jerks, while in No. 11 par?esthesia, hyperaesthesia 

 of the calf muscles, cardiac disturbances, loss of knee jerks, and 

 development of foot drop occurred. In No. 7 the most striking 

 symptoms suggesting the development of beriberi were anfes- 

 thesia and paraesthesia of areas of the skin, hyperiesthesia of 

 the calf muscles, and cardiac disturbances. The knee jerks 

 were absent before the experiment commenced and remained 

 so. In No. 12, cardiac disturbances, pain and tenderness of 

 the calf muscles, and oedema of the legs occurred. 



The loss of weight in the subjects comprising this group 

 during the experiment was as follows : 



Group II. 



Case. 



Lost— 



Kiloerrams. 



1 

 Equivalent 

 in pounds. 



No. 7 



6.1 

 4.6 

 6.1 

 2.7 

 3.6 

 3.4 



13.6 

 10.0 

 13.6 

 6.0 

 8.0 

 7.6 



No. 8« - 



No. 9«- - 



No. 10" 



No. 11 • 



No. 12 .-.. - 





* Developed beriberi. 



In considering the cases of Group IV, we find that in case 

 No. 20 the most striking symptoms of beriberi which developed 

 during the course of the experiment were cardiac disturbances, 

 pain and tenderness in the calf muscles, and loss of knee 

 jerks. In case No. 26 there occurred hypersesthesia of the skin 

 over the fingers and toes, loss of power of the grip of the hands, 

 loss of knee jerks, and unsteadiness when standing with the 

 eyes closed. In No. 25 the striking symptoms were weakness 

 of the legs and tenderness in the calf muscles, and slight oedema 

 of the legs, while in No. 29 marked oedema of the legs and 

 face, epigastric pain, loss of knee jerks, cardiac disturbances, 

 and collapse were the prominent symptoms. In case No, 19 the 

 suggestive symptoms w^ere pain in the legs and arms, the feeble- 

 ness of the grip of the hands, paraesthesia and slight tenderness 

 of the calves, and slight oedema over the tibiae, while in No. 22 



