OFFICIAL INSPECTION 26. QI 



are peculiarly likely to return again and again, and the remedy 

 has but a temporary effect ; hence the dose must be repeated, 

 and in time the patient may become dependent upon the drug. 

 Furthermore, the ache or pain for which the medicine was 

 first taken is often worse than ever after the effects of the 

 remedy have passed away, because of the weakened condition 

 of the system which may result from the use of these agents, 

 and hence there is additional call for the remedy. Thus a 

 habit may be established — more drug, impaired bodily health, 

 lessened resistance, more pain, more drug." 



The above in no v/ay conflicts with the employment of these 

 remedies by physicians. It clearly indicates that the ingestion 

 of these powerful drugs without medical advice is dangerous. 



Methods of Analysis. 



Acetanilid was determined by Seidell's method (Jour. Amer. 

 Chem. Soc. 1907, 29, 1091) in which it is saponified with dilute 

 HCl (hydrochloric acid) and then titrated with a standard 

 bromate of potash solution. 



When acetphenetidin was present an accurate determination 

 was not attempted as at present we have no very satisfactory 

 method of determining it. It is, however, soluble in chloro- 

 form and most of the other materials entering into headache 

 powders, as sodium bicarbonate, sugar, etc., are not. So a 

 fairly accurate determination of the acetphenitidin can be made 

 by leaching the powder with this reagent, evaporating off the 

 chloroform, drying and weighing. When botli acetanilid and 

 acetphenetidin were present the chloroform extract represents 

 both these ingredients. In case the acetphenetidin was present 

 in small quantity it was not difficult to titrate the acetanilid and 

 make an approximate separation. 



Results of Analysis. 



The results of the analysis are given in the tables on pages 

 92-96. 



The goods were all lawfully labelled and accorded fairly with 

 their professed strength. In some instances there was alto- 

 gether too large a difference in the weights of the individual 

 powders. The adult dose given in the U. S. Pharmacopoeia 

 for acetanilide is 4 grains and for acetphenetidinuni (phenaci- 

 tine) 7>4 grains. No single powder or pellet in those examined 

 carried appreciably more than the adult dose. 



