SEX STUDIES VII. CYSTIC DEGENERATION OF THE OVARIES. /I 



Eine veils tandige Gleichwentigkeit der Keirtidrusen mit denen 

 der normalen Tiere wird nie, auch nach vielen Monaten nicht 

 erreicht. 



"Alle diese trophisohen Storungen werden in gleicher Weise 

 durch die Exstirpation der ganzen Hypophyse ebenso wie durcn 

 die Exstirpation des-Vorderlappens a'llein hervorgerufen. 



"Der Hinterlappen der Hypophyse mft diese Ersoheinungen 

 bei seinem Ausfall nicht hervor," 



Goetsch and Gushing^ have lately shown that the feeding 

 of the dessicated extraot of the anterior lobe of the hypophysis 

 to young rats of both sexes "has a markedly stimulating effect 

 upon the growth and development of the reproductive glands." 

 This was evidenced both by the histological condition of the 

 sex glands and the early and frequent breeding of the treated 

 animals. Posterior lobe extract has no such effect. 



Adler" has shown that in Rana temporaria and Pelohates 

 larvae, hj-poiphysectomy inhibits the development O'f the sex 

 glands. 



It seemed highly desirable, in view of the above mentioned 

 results, to determine what effect the continued injection of an- 

 terior lobe substance wbuld have in the case of this cow 

 Dorothy of Oron'o, whose sexual functions were deranged in 

 the manner already indicated. 



As material! for these experiments we used the dessicated 

 powdered substance of the anterior lobe of the pituitary glands 

 of .cows. This material we obtained from the Organotherapeu- 

 tic Department of Armour & Company in Ghicago. The pro- 

 tocols of the experiment follow. 



November 25. Injected 1-2 gram of dessicated pitui- 

 tar}- body anterior Idbe mixed with 18 cc. 0.9 per cent. 

 XaCl solution into the jugular vein at 10.30 A. ]\I. No 

 ill eff'ects observed. Temperatures (Fahrenheit and' rectal 

 in all cases)— 12 'M., 101.4; 3 P. M., 101.8; 5 P. M., 101.8; 

 morning of November 26, 101.4. (This was the second 



"Goetsch, E. and Gushing, H. The pars anterior and its relation to the 

 reproductive glands. Proc. Soc. Exp. Biol, and -\Ied., Vol. XI, pp. 26-27, 

 1913- 



^A.dler, L. ^Nletamorphosenstudien an Batrachierlarven. I. Extirpation 

 endokriner Driisen. Arch. f. Entwickl., Bd. 39, pp. 21-45, I9I4- 



