CERTAIN ALKALOIDAL PERIODIDES. 



269 



Very similar results were secured with a solution of bromine in potas- 

 sium bromide. 



Table X. — Action of Wagner's reagent with aqueous solutions of heroin. 



Kumber 

 of exper- 

 iment. 



Grams 

 alkaloid. 



jq iodine- 



Atoms of iodine 



per molecule 

 of alkaloid in— 















Added. 



Used up. 



Solution. 



Perio- 

 dide. 







cc. 



ee. 







86 



0.0084 



1.00 



0.72 



4.4 



3.16 



S7 



0.0084 



1.89 



1.10 



8.3 



4.83 



88 



0.0084 



5.72 



1.69 



25.1 



7.43 



89 



0.0084 



10.05 



2.08 



44.2 



9.14 



90 



0.0084 



15.63 



2.34 



68.7 



10.28 



91 



0.0084 



25.72 



2.92 



113 



12.83 



92 



0.0084 



50.87 



3.16 



223 



12.89 



93 



0.0084 



100.74 



6.17 



446 



27.89 



94 



0.0084 



100.74 



5.48 



446 24. 08 



It is evident that with heroin also, the amount of iodine combining 

 with the alkaloid is dependent on the concentration of iodine in the 

 solution. The precipitates were apparently similar to those obtained 

 in acid solution. As was the case with codeine, clear filtrates were 

 secured only with low concentrations of iodine and the results must 

 consequently be considered as somewhat inaccurate. 



The following determinations, made with the same heroin solution, 

 are of interest in further defining the effect of the presence of acid: 



Table XI. — Influence of acidity. 



Num- 

 ber of 

 ex- 



Gramis 

 alkaloid. 



tL iodine — 



Remarks. 



Atoms 

 iodine 

 per mole- 

 cule in 

 perio- 

 dide. 



ment. 





Added. 



Used up. 



87 



95 

 96 



97 



98 



99 



100 



0.0084 



0.0084 

 0.0084 



0.0084 

 0.0084 

 0.0084 

 0.0084 



cc. 

 1.89 



2.00 

 2.00 



2.00 

 2.00 

 2.00 

 2.00 



cc. 

 LIO 



0.T8 

 0.95 



0.64 

 0.43 

 0.15 

 0.24 



Detenninations made in the usual 

 manner. No acid present. 



flodine added to the alkaloid, no 

 acid present. Solution shaken 

 several minutes, filtered and ti- 

 trated. 



f Iodine added to alkaloid, then 



[ 0. 25 gram H2SO4 added. 



(0. 25 gram HjSO^ added to alkaloid, 



I then iodine added. 



4.83 



3.82 



]■ 2.37 

 '. 0.89 



