CERTAIN ALKALOIDAL PERIODIDES. 

 Table XII. — Absorption of iodine vapor hy dry alkaloids. 



271 



Time. 



6 hours . 



1 day _.. 



2 days-. 



3 days .. 



4 days .. 



5 days-- 



6 days — 



7 days — 



8 days_- 



9 days _. 



11 days - 



12 days . 



13 days . 



14 days . 



15 days . 



16 days - 

 18 days _ 

 20 days . 

 22 days . 

 24 days . 

 27 days . 

 32 days . 

 38 days . 

 44 days - 

 51 days - 

 61 days. 



75 days _. 

 99 days .. 

 133 days . 

 200 days . 



Morphine. 



Grams 



iodine 



taken up 



0.0126 

 0.0618 

 0. 1362 

 0. 2593 

 0. 3636 

 0. 4758 

 0. 6171 

 0. 6998 

 0. 7943 

 0. 8902 

 1. 1386 

 1. 2785 

 1. 4273 

 1. 5822 

 1. 7212 

 1. 8380 

 2. 0402 

 2. 1886 

 2. 2836 

 2. 3831 

 2. 4562 

 2. 5224 

 2. .5666 

 2. 5893 

 2. 5983 

 2. 5985 



Atoms 



iodine 



per 



molecule 



alkaloid 



0.04 

 0.19 

 0.42 

 0.79 

 1.11 

 1.45 

 1.88 

 2.14 

 2.42 

 2.72 

 3.48 

 3.90 

 4.36 

 4.83 

 5.25 

 5.61 

 6.23 

 6.68 

 6.97 

 7.27 

 7.50 

 7.70 

 7.83 

 7.90 

 7.93 

 7.93 



Codeine. 



Grams 



iodine 



taken up 



0.0515 

 0. 1813 

 0. 3351 

 0. 4780 

 0. 6208 

 0.7755 

 0. 9025 

 1. 0301 

 1. 1640 

 1. 2708 

 1. 4767 

 1. 5180 

 1. 6214 

 1.6700 

 1. 7185 

 1. 7792 

 1.8413 

 1. 9136 

 1. 9873 

 2. 0536 

 2. 1137 

 2. 1875 

 2. 2373 

 2. 2538 

 2. 2553 

 2. 2379 

 2. 2305 

 2. 1730 

 2. 1822 

 2. 1477 

 2. 1075 



Atoms 



iodine 



per 



molecule 



alkaloid. 



0.22 

 0.76 

 1.41 

 2.01 

 2.61 

 3.26 

 3.80 

 4.33 

 4.90 

 5.35 

 6.21 

 6.60 

 6.82 

 7.03 

 7.23 

 7.49 

 7.75 

 8.05 

 8.36 

 8.64 

 8.90 

 9.20 

 9.42 

 9.48 

 9.49 

 9.42 

 9.39 

 9.15 

 9.18 

 9.04 

 8.47 



Heroin. 



Grams 



iodine 



taken up. 



0. 0135 

 0. 0495 

 0. 0981 

 0. 1597 

 0. 2265 

 0. 3095 

 0. 3925 

 0. 4598 

 0. 5188 

 0. 5670 

 0. 6895 

 0. 7748 

 0. 8371 

 0. 8927 

 0. 9415 

 0. 9635 

 0. 9874 

 1.0218 

 1. 0523 

 1. 0821 

 1.0985 

 1. 1157 

 1. 1295 

 1. 1339 

 1.1393 



1. 1395 

 1. 0941 

 1. 1544 

 1.1718 

 1.1709 



Atoms 



iodine 



per 



molecule 



alkaloid 



0.10 

 0.35 

 0.69 

 1.12 

 1.61 

 2.18 

 2.77 

 3.24 

 3.66 

 4.00 

 4.86 

 5.47 

 5.90 

 6.30 

 6.64 

 6.80 

 6.97 

 7.20 

 7.42 

 7.63 

 7.75 

 7.87 

 7.97 

 8.00 

 8.04 



8.04 

 7.71 

 8.14 

 8.27 

 8.26 



A graphic presentation of the data for the first thirty-eight days is 

 given in the curves of figure 3. 



It was discovered that the vapor of iodine had attacked the pans of 

 the balance, disturbing the equilibrium to the extent of slightly more 

 than three milligrams, so that a minus correction of 0.0033 gram should 

 be applied to the weight recorded at the end of the experiments. 



After fifty-one days, equilibrium had apparently been reached, and 

 at this point the corrected weights give the following rations : Morphine, 

 7.92 atoms of iodine per molecule of alkaloid; codeine, 9.47; and heroin, 

 8.02. The morphine periodide was then removed for a purpose referred 

 to later and the others left for further investigation. Instead of show- 

 ing further gain in weight, heroin remained constant, while codeine 



