THE PHILIPPINE 



Journal of Science 



B. Medical Sciences 



Vol. VI "^^ovEMBEE, 1911 'No. 5 



ADDISON'S DISEASE AND ADRENAL TUBERCULOSIS. 



By B. C. Cbowell. 



{From the Pathological Laboratory of Bellevue Hospital, New York, and the 

 Biological Lahoratory, Bureau of Science, Manila, P. 1.) 



INTRODUCTION. 



Extensive clinicaL pathologicaL and experimental investigations into 

 the pathogenesis of the symptom-complex described b}' Addison have to a 

 large extent failed to elicit any more positive knovs^ledge of the subject 

 than was originally possessed by that author. Universal recognition has 

 been accorded the establishment of the symptom-complex of asthenia, 

 anaemia, pigmentation of cutaneous and mucous surfaces, with nervous 

 and gastro-intestinal disturbances as a clinical entity, and its frequent 

 association with destniction of the adrenals bj' tuberculosis. However, 

 the problems of the pathological anatomy and physiology of this disease 

 have become increasingly difficult proportionately to the number of its 

 investigators. 



That Addison's disease and tuberculosis of the adrenals are frequently 

 associated and that there is some causal relationship between them is 

 generally admitted ; still the occun-ence of apparently unequivocal cases of 

 Addison's disease without adrenal destniction, and cases of adrenal de- 

 struction by various causes without the appropriate sj^mptoms, has fur- 

 nished many difficulties in the solution of the problem. In 370 cases 



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