422 
before, leaving his head above the water; in’31 minutes he 
became quite paralyzed as before, placing the forelegs upon 
his back with the palms upwards. Death finally ensued in 
43 minutes, with the same appearances as those described in 
the first experiment. 
Third Experiment.—Strychnine. 
Inthisexperiment 5 grains of pure strychnine were dissolved 
in a minimum of muriatic acid, and 5 ounces of water added. 
A frog was placed in the bath thus formed, with the following 
results:—Tetanic convulsions set in immediately upon his 
touching the liquid, and continued while life remained ; there 
was no sign of opisthotonos, but strongly marked emprostho- 
tonos. The animal was quite dead in 4 minutes; mouth open, 
and eye closed and death-like; the whole body stretched out 
and bent forwards, the back being highly arched. 
Fourth Experiment.— Strychnine. 
A bath was made of 5 grains of strychnine and 20 ounces 
of water, and a frog placed in the solution, as before. The 
animal became speedily convulsed, and exhibited the same 
symptoms as in the former case; but in this case death did 
not finally take place until after an interval of 55 minutes. 
The mouth was open, the eye closed and dead, and the body 
arched and bent forwards, as before. 
Fifth Experiment.—Nicotine and Strychnine. 
In this experiment, two baths were prepared; one of 5 
grains of strychnine to 5 ounces of water, and the other of 
5 grains of nicotine to 5 ounces of water, and the two solu- 
tions carefully mixed together. A frog was now introduced, 
and remained apparently without inconvenience for 19 minutes, 
when the strychnine began to operate, and the first tetanic 
convulsion appeared ; the usual appearance of strychnine poi- 
soning continued, but with less violence than in the former 
experiments; after 47 minutes the animal was removed from 
