423 
the bath, and washed with cold water; he lived afterwards 
for upwards of 24 hours, exhibiting at intervals tetanic con- 
vulsions. 
Sixth Experiment.—Nicotine and Strychnine. 
Another frog was placed in a mixed bath of nicotine and 
strychnine of the same strength as that last described, and 
removed after an interval of 10 minutes. After removal, in 
32 minutes, the first symptom of emprosthotonos appeared, 
and the convulsions continued for many hours; but the ani- 
mal ultimately recovered completely, and is still in the enjoy- 
ment of health and life, after a lapse of many days. 
The last two experiments appeared to Mr. Haughton con- 
clusive as to the action of nicotine in retarding, and, in certain 
cases, completely counteracting the effects of strychnine. In 
the fifth experiment, a frog had lived for 47 minutes in a 
mixture of two solutions, of which one would have destroyed 
life in 4 minutes, and the other would have produced paraly- 
sis in 1 minute, and destroyed life in 23 minutes; and yet, 
in the mixture, the animal had lived for 47 minutes, and 
afterwards for 24 hours. 
In the sixth experiment, the frog immersed in a similar 
mixture of the poisons for 10 minutes had ultimately reco- 
vered; the effect of the strychnine being completely obviated 
by the action of the nicotine. 
Mr. Haughton considered that these facts which had come 
under his notice, gave rise to much interesting speculation, 
into which, however, he had no desire to enter, as he pre- 
ferred leaving such topics to those who were more immediately 
concerned in them; and he expressed a hope that further in- 
quiries would be instituted into the action of strychnine and 
nicotine upon some of the warm-blooded animals, as he be- 
lieved that in nicotine, which was always easily procurable in 
the form of tobacco-leaf infusion, would be found a valuable 
antidote in at least some cases of strychnine poisoning, whether 
intentional or accidental. 
