86 
this case induces me to publish some of my experiments of January, 
1857, in the hope that the subject may be taken up by some person 
more competent than myself to do it justice. 
No. I.—Strychnia and Nicotine. 
SMALL CURLY DOG. 
Minutes. 
1, Administered one grain of strychnia in’a small piece of 
MEAL! <2 Oo PLE A eee Ba Ae Tay CG 
2. Slight spasm and twitching of extensors, . . . . . 15 
3. Gave 0-6 grainof nicotine inbread, . . . ... =. 17 
4. Hind-legs rigid, but dog lively, . . . ett lic 
5. Fell in tetanic spasms, characteristic of strychnia, . . 21 
6. Gave five drops = three grains nicotine, intomouth, . . 22 
Death nearly instantaneous, rigidity of muscles quite gone. 
7. Quite dead, bladder voided,. . . . ... é 
Pupils greatly dilated. 
Post-mortem. 
1, Lungs pale and collapsed. 
2. Heart greatly engorged. 
3. Blood coagulates naturally. 
4. Stomach natural. 
26 
‘The meat was scarcely acted upon, although the dog had fasted for 
twenty-four hours; to all appearance, the greater part (ths) of the 
strychnia remained not acted upon by the juices of the stomach in the 
cavity of the small piece of meat in which it had been originally placed. 
It is evident that this dog died of an over-dose of the nicotine, adminis- 
tered as an antidote. ; 
No. I1.—Strychnia alone. 
SMALL BLACK TERRIER, 
Minutes. 
1. Administered 1 gr. strychnia, in meat, 
2. Slight twitching of extensors, . . . . . . . . 18 
3. Dog staggered on attempting tomove, . . . . . 60 
4. Slight rigidity of extensors, and partial loss of power 
of volition, BOS ti OSS Ry ers Ee 
5. Ranting ‘and restiless; (iv). Liss) quite hh ke 
6. Fell over in tetanic convulsions, . . . . .. . WW 
Violent convulsions over whole body, with marked 
opisthotonos, particularly in the neck; quick breath- 
ing and panting in the intervals of the convulsions; 
continued in this state for one minute, and recovered. 
7, Hell over againfasibefore 2) 9h Se oe ee 
8. Voided bladder, and died, . . . payee ea 71 
Muscles not rigid after death. | 
