449 



blood ceased to flow, I found not only granules, but granular 

 corpuscles, hyaline vesicles, and granular masses. In another 

 instance, one hour after the receipt of a wound in the hand, I 

 examined the exudation, and found a well-marked granular 

 base of considerable extent, abundance of granules, and a few 

 examples of nucleated cells. 



7. The observations of Robin and Handfield Jones, on the 

 development of fat, likewise prove a mode of groAvth not re- 

 concilable with the nucleo-cellular doctrine. 



8. Another class of proofs may be deduced from the re- 

 sults of experimental or artificial Histogenesis, which go to 

 prove the direct formation of tissues, without the intervention 

 of cells. 



Thus, in the well-known experiment of Ascherson, the 

 contact of oil and albumen, two homogeneous fluids, gives rise 

 to the formation of granules, granular base or stroma, vesicles, 

 and simple membrane (hyaline membrane). 



The experiments of Panum show the possibility of artifi- 

 cially forming granules, vesicles, and granular corpuscles. 



The results obtained by Melsens, and fully confirmed by 

 microscopic examination of his " tissu cellulaire artificiel" both 

 by M. Gluge and myself, give us instances of the direct for- 

 mation of at least three elements of organic bodies, indepen- 

 dently of cells, viz., granules and granular base, fibres, and 

 corpuscles.* Similar results have been obtained by Parkes. 



I am able to furnish another and valuable class of proofs 

 from the results of my researches in Histolysis, which show, 

 as will be fully detailed further on, that structures can originate 

 under conditions when Ave cannot suppose any vital organic 

 influence to be present, but when such forces as attraction, 

 cohesion, fusion, endosmose and exosmose, and the mutual 



* For an account of Melsens' experiments, see Dublin Quarterly Journal 

 of Medical Science, February, 1852. For Panum's experiments, see Lyons' 

 Annals of Micrology, British and Foreign Medico-Chirurgical Review, April, 

 1853. 



