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Drlg Stimulation. The most common is that of opium or its alka- 

 loids, cocaine coming perhaps next. Hasheesh effects I have not observed. 

 Not all persons are stimulated after the fashion of DeQuincey. Some 

 brains are stimulated but little or not at all. The same is true of alcohol. 

 The effect depends, moreover, largely on the dosage, varying from a more 

 or less transient stimulation to- complete stupor. It should be kept in 

 mind that to a large extent anodynes that depress, such as acetanilid. are 

 now used in place of opium. 



Coffee. This is an active stimulant to some ; many know that it will 

 keep them awake at night, as night nurses. Some persons say coffee 

 makes them dream. Literary workers may be actively stimulated by it. 

 their thoughts flowing freely after its use. 



Mania. An individual delirious in acute mania is a sight never to 

 be forgotten. The delirium may continue for days, even for weeks, until 

 the body is physically exhausted. Compared with this, the amount of 

 mental work an ordinary brain worker does seems insignificant, and the 

 idea of nervous prostration from mental overwork is made to appear 

 ridiculous. 



Recurrent Mania. This recurs at intervals, depending on the indi- 

 vidual, after days, weeks, months, or even years. 



Alternation of Mania and Melancholia. In this there are periods 

 when the mind is very active, followed by periods of the opposite extreme. 

 One of my insane patients during a period of exaltation had Cacoethes 

 scribendi, the mania to write, and wrote me his autobiography; it would 

 form a fair-sized book if put into print. He wrote continuously, 

 did not even want to take time for meals or to sleep at night. 



Chronic Mania. In this condition many individuals see visions and 

 hold imaginary conversations ; at times the brain is very active. 



Dementia. At times when there is some disease producing fever 

 there may be a transient lighting up of the mental faculties in dements, 

 subsiding again with the subsidence of the fever. A study of such cases 

 often sheds light on the mental processes in the normal, or sane. 



Epilepsy. Epileptics about the time of an oncoming seizure may have 

 active mental stimulation ; the fact that some see visions is well known. 



