PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 431 
the spinal reflexes were apparently gone; the conjunctival reflexes were 
present; there was profuse salivation. The muscles of the entire body 
were whoily relaxed when the animal was removed from the tank, but 
soon all of the legs became extended and rigid. This condition gradually 
passed off and the animal showed signs of recovery. By 11.30 p. m. 
the deg had regained consciousness and was able to stand on its feet. 
It waiked slowly, with a trembling, staggering, uncertain gait and without 
aim. 
August 31 — The animal was found to have greatly improved. It refused 
food, however, and howled when the back of its head was touched. It 
would press its head against the attendant’s legs or other objects, and 
remain thus for hours. 
Sepiember 1—'The dog was found normally active, eating meat and 
drinking water freely. No other effects followed. 
September 22, 1916 — Dog fumigated a second time, this time at 23° C. 
for a period of six hours. 
Time when fumigation was begun, 11.10 a. m. 
Time when fumigation was finished, 5.10 p. m. 
Observations: At 11.15 a. m. the dog was observed licking its chops. | 
At 11.30 it was panting at intervals as if short of breath. At 12 m. it was 
slightly drowsy. At 12.05 p. m. it was unsteady, sitting on its haunches 
but keeping this position apparently with difficulty. At 12.10 it lay 
down in a natural position and closed its eyes; it would open its eyes 
when one rapped at the tank, but would immediately close them again. 
At 12.20 the dog’s head was raised and the breathing was slow and 
labored. At 12.30 the animal appeared slightly confused, and uncertain 
as to the direction of the sound when one tapped on the tank. At 12.50 
the animal stood up when called and walked across the chamber, but 
immediately went back and lay down again. From that time until 
5.10, when it was removed from the tank, the animal lay quiet but alert 
as if sensing some danger. After the dog was removed from the fumigation 
chamber fresh vomit was found in the tank, which had probably been 
emitted while the chamber was being opened. A copious secretion of 
saliva was observed and the animal was slightly unsteady on its feet. 
It refused water. 
