432 WALLACE LARKIN CHANDLER 
September 26 —The animal had apparently recovered and no symptoms 
of the action of the drug appeared until on this day (four days after exposure 
to the vapor) when the attendant observed that the dog had difficulty 
in using its hind legs. An examination was made and the animal appeared 
normal. This was about 9 a.m. By 11 a. m., however, incoordination 
of the muscles of the hind legs was obsérved and the animal walked with 
a peculiar sprawling gait. This condition became more pronounced as 
the day advanced, and by 3 p. m. it was almost impossible to.induce 
the animal to walk at all. Its tendency was to crawl into dark corners 
and hide. Finally the animal refused to remain on its feet, and when 
placed on its feet it would stumble and fall down again. However, at 
4.30 p. m., after a considerable period of rest, the dog walked into its 
kennel with a slow, staggering, sprawling gait. 
September 27 —'There was evidence that the dog had thrashed about a 
good deal during the night and it was found lying prone on its side in the 
kennel. The animal appeared conscious, but was very irritable and 
thrashed about considerably. At 3 p. m. pronounced nystagmus was 
observed; the left pupil was dilated, the right pupil was contracted, and 
the jaws were set. At 4 p. m. the animal showed a tendency to remain 
on its left side; when turned on its right side, it executed a right-to-left 
rotation, finally coming to rest on the left side. The animal seemed to be 
conscious and wagged its tail when spoken to. The flexor muscles of the 
hind legs were in a state of tense tonic contraction, drawing the legs up 
against the body. The animal would neither eat nor drink. The anal 
temperature was 37.8° C. 
September 28 —'The general condition of the animal was about the same. 
The trunk muscles were tremulous, the extensor leg muscles contracted. 
The legs were withdrawn once or twice when touched, but finally they 
failed to react even to the prick of a pin, so tense was the muscular con- 
traction. The animal made swallowing movements and could work its 
jaws to some extent, swallowing water when placed in its mouth. 
Nystagmus was not so pronounced. The anal temperature was 38.3° C. 
September 29— The animal appeared to be somewhat improved. 
Nystagmus was decreasing. The dog swallowed milk when placed in 
its mouth. The flexor muscles were relaxed. Clonic movements of the 
