PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 433 
hind legs were observed. The anal temperature was 39° C. The heart 
rate was increased only when the animal struggled, but was a trifle 
irregular. 
September 30 — The animal was very much improved. It ate chopped 
meat and drank milk, and could raise itself a little. Its head waved about 
in an uncontrollable manner. The anal temperature was 38.5° C. 
October 1—Still more improvement was observed. The dog could 
almost regain its feet. It refused water, but drank milk without urging. 
In the afternoon the animal was able to stand on its feet; it walked eight 
or ten steps, and then staggered and fell. The anal temperature was 
oof ©. 
October 2— The animal walked fairly well, but staggered a great deal. 
It ate greedily. 
October 3— The animal had regained nearly the normal use of its legs 
and was found running about with other dogs. This dog finally recovered 
entirely and never developed any further symptoms. 
It is interesting to note that this animal exhibited symptoms just the 
reverse of those described by Filehne as following a retarded action of 
the drug (page 424). 
DOG II (MALE) 
Weight of dog, 11.5 kilograms. 
September 1, 1916 — Dog fumigated at 25° C. for a period of two hours and 
fifty-nine minutes. 
Time when fumigation was begun, 12.40 p. m. 
Time when fumigation was finished, 3.39 p. m. 
Observations: Soon after being introduced into the chamber, the 
animal was observed to lick its chops; it panted at intervals; respiration 
was accelerated. At 1.45 the animal appeared restless, howling a good 
deal; it appeared to stagger. At 2.30 the animal was unable to remain 
on its feet; it lay on its side, with the extensors of all legs in tonic con- 
vulsions. At 2.50 the condition was about the same as at 2.30. At3p.m. 
the dog made sounds as if it was becoming anesthetized; there were clonic 
convulsions of the extensor muscles of the fore legs, and occasional clonic 
convulsions of the extensors of the hind legs followed by general abdominal 
