434 WALLACE LARKIN CHANDLER 
muscle tremors; respiration was quickened, with periodic long, deep 
inhalations; the dog was apparently unconscious, and could not be aroused; 
the eyes were open and winking; there was nothing abnormal about the 
pupils, and no nystagmus. At 3.04 the condition was about the same; the 
dog moaned at intervals. At 3.24 the respiration was 40, and increased 
in depth with periodic long, deep inhalations as before. At 3.25 there 
was opisthotonos, the convulsions lasting for about one-half mimute 
and being followed by accelerated respiration. At 3.27 the respiration 
was 52. At 3.385 the respiration was shallow. At 3.39 the animal was 
removed from the tank; the muscles of the entire body were relaxed, 
but soon the leg muscles stiffened; the tongue and the lips were cyanotic. 
At 340 the respiration was irregular, gasping; the animal was given 
artificial respiration and oxygen, but it died at 3.50. 
The body was opened immediately. The heart blood was of a chocolate 
color; the lungs were a dark gray; the intestines were hyperemic; the 
liver and the spleen were coffee-colored. 
In this case the type of symptoms described by Filehne as following 
a rapid action of the drug were undoubtedly shown. 
DOG IV (FEMALE) 
Weight of dog, about 12 kilograms. 
September 27, 1916 — Dog fumigated at 21.5° C. for a period of ten hours. 
Time when fumigation was begun, 8.30 a. m. 
Time when fumigation was finished, 6.30 p. m. 
Observations: Immediately after being introduced into the fumigation 
chamber the animal lay down and went to sleep. It scarcely moved 
from this position during the entire ten hours; when the observer tapped 
on the tank the animal would open its eyes; when the tapping was loud 
it raised its head but seemed confused and could not follow the sound. 
At 4.30 p. m. the respiration was observed to be decidedly increased. 
At 5 p. m. the observer tapped loudly on the tank, and the animal opened 
its eyes but did not raise its head, tho it appeared normal. When removed 
from the tank at 6.30, the animal was lively, eating and drinking freely, 
and depositing a great quantity of apparently normal urine. This animal 
developed no symptoms of poisoning afterward. 
