PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 435 
DOG V (FEMALE) 
Weight of dog, 11.2 kilograms. 
October 26, 1916 — Dog fumigated at 20° C. for a period of twelve hours. 
Time when fumigation was begun, 8.30 a. m. 
Time when fumigation was finished, 8.30 p. m. 
Observations: The animal rested quietly during the entire course 
of the experiment, and was removed from the tank apparently unharmed. 
It ate heartily of roast beef and showed no symptoms of poisoning during 
the next three days. 
October 29 — The animal vomited when it was taken out of the kennel, 
but no other symptoms were especially noted during the day. 
October 30 — The animal was found on its side and was unable to stand. 
The following symptoms were observed: lack of coordination of the muscles 
of the extremities; neck muscles rigid and head drawn back on the body; 
ventroflexion of back; fore legs drawn up to the body; one or both hind legs 
involved in clonic convulsions; nystagmus. 
October 31 — The condition was slightly improved. The fore legs were 
drawn up as before; the hind legs were extended, but were flexed on the 
body. The right pupil was widely dilated and the left pupil was con- 
tracted; this is just the reverse of the pupillary reactions observed in 
Dog I. Nystagmus was still in evidence. The neck muscles were not 
so rigid. The dog was very restless all day, but quieted down toward 
evening. It swallowed milk when placed in its mouth. 
November 1 — There were no signs of nystagmus. The general condition 
was very much improved. The dog swallowed milk when placed in its 
mouth. The leg muscles were not particularly involved. Both pupils were 
widely dilated. The animal appeared to be conscious but did not howl. 
November 2 — The dog’s condition was very much improved. It noticed 
the observer as soon as he entered the room. The animal took milk 
freely. Nystagmus was observed at times. The pupils were somewhat 
dilated. The animal was able to raise its head. 
November 3—The condition was still more improved. The animal 
drank milk and water readily. Its head was raised. Its fore legs were 
folded beneath the body, but were stiff. 
