PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 439 
Observations: The dog appeared restless during most of the time it 
was in the fumigation chamber. At 1.30 p. m. it had vomited. At 5 
p. m. it was observed to be unsteady on its feet; it staggered and fell, 
regained its feet, and fell again. At 5.30, when it was removed from the 
tank, the animal was able to walk but staggered about very much as if 
it had been intoxicated with alcohol; it ate cooked meat. 
December 5— The animal was found lying on its side in a helpless con- 
dition; the tongue and the lips were cyanotic; the skin temperature 
was very low; the heart rate was 70, but was regular; the respiration 
was regular, as if from disorganization of the respiratory center, and 
was difficult to count; the conjunctival reflex was good; the dog was 
unable to move its legs; tremors were observed in the leg muscles, the 
abdominal muscles, and the lips; the jaws moved incessantly, as if the 
animal was gasping for breath;.the dog was placed in a warm room on 
a piece of cotton. The animal’s condition remained unchanged during 
the remainder of the day; its respiration was always shallow and 
uregular. At 7 p.m. it was found dead. A post-mortem examination 
showed the following: heart distended and all the chambers filled with 
ante-mortem clots; these clots also appeared in the larger blood vessels; 
the stemach was very distended and was filled with gas and undigested 
food; the duodenum was filled with a sticky, bloody mucus; the jejunum 
contained a dark brown mucous substance; the blood was a trifle 
darker than normal. 
In this case asthenia appeared to be the principal symptom. The 
action of the drug was rapid, but did not cause the type of convulsions 
described by Filehne as following a rapid action of the drug. 
DOG X (FEMALE) 
Weight of dog, ? (medium-sized). 
December 7, 1916 — Dog fumigated at 20° C. for a period of seven hours 
and fifty minutes. 
Time when fumigation was begun, 2.10 p. m. 
Time when fumigation was finished, 10 p. m. 
Observations: The animal remained quiet during the fumigation, and 
when removed from the tank at 10 p. m. it appeared entirely normal. 
No symptoms of poisoning appeared until two days later. 
