440 WaLLACE LARKIN CHANDLER 
December 9 — At 9 a. m. the animal was apparently normal. At 3 p. m. 
it exhibited a weakening of the hind legs, and walked with a staggering, 
sprawling gait, showing a lack of coordination of the muscles of the 
hind legs; it had recently vomited. At 5 p.m. the anima! was no longer 
able to walk, and the extensors of the fore legs were in tetany. At 
6 p. m. the animal was no longer able to stand; nystagmus had appeared, 
and both pupils were dilated, the left more widely than the right; the 
dog drank a little milk. 
December 10 — The general condition of the animal was about the same 
as on the preceding night. Nystagmus was slight. The dog drank 
milk and water in the morning, but refused both food and drink later 
in the day. The legs were extended; there was nothing definite about 
the extension of the legs, one or both of the hind legs sometimes being 
extended and rigid, and the fore legs sometimes being thus affected; 
at times the tetany would last for a long period, and again it would 
be of short duration. At times the head was drawn strongly backward, 
with the muscles of the neck rigid. The pupils reacted shghtly to 
light. There was an odor of nitrobenzene on the animal’s breath. 
December 11 — At 8 a. m. the general condition of the animal was worse, 
but it was still conscious; all the legs were rigidly extended for minutes 
at a time, and the head was drawn backward; when this condition passed 
off the animal was left prostrated; the pupils were contracted unequally. 
At about 1 p. m. the animal passed about 100 mils of dark urine (the 
first passed since the fumigation). At 10 p. m. the pupils were about 
normal; the animal swallowed a very little milk and water when these 
were placed in its mouth; when disturbed, the animal would attempt 
to use its legs, and this resulted in a tetanic convulsion involving the 
muscles of the legs and the neck. 
December 12 — During the night the animal passed about 100 mils of 
very dark urine (almost like black coffee). The animal had regained the 
ability to move its legs a little, tho an attempt to do so usually threw 
them into tetany of the type described above. At 11 a. m. the animal 
was found with all four of its legs in constant motion; these movements’ 
were fairly well coordinated and rapid, as in the act of running or swim- 
ming; they would increase in rapidity and violence until the animal was 
thrown into a convulsion which apparently involved every muscle of the 
