PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 441 
body; the legs were straight and the head was drawn down under the body 
between the hind legs; these spasms lasted for a few seconds, during which 
respiration ceased entirely; as the spasms passed off, the animal would 
give a short, hollow cry and resume the running movements, tho with 
evidence or exhaustion; both the heart rate and the respiration were 
rapid; if the animal was lifted up or its legs were held for a moment, 
the swimming or running movements would cease for a time; the excite- 
ment was very similar to postanesthetic excitement, except for the convul- 
sive periods. At 3.30 p.m. the animal was found quiet and relaxed; the 
respiration was 35. At 5 p. m. the animal swallowed a little milk and 
water which were placed in its mouth. At 10 p. m. convulsions were 
observed which were of the opisthotonos type except that the muscles of 
the hind legs were relaxed; these convulsions appeared at intervals, and 
were induced if the animal was disturbed. 
December 13 — The animal was able to swallow but a very little liquid 
food when this was placed in its mouth, and so had had little or no 
nourishment. It lay on its left side, with its head drawn back on its 
body, its fore iegs extended and rigid, and one or both of its hind legs 
drawn up to its body. The respiration was slow, 16-20, and was deeper 
than normal; the heart was regular, the rate being about 160; the 
tongue and the conjunctiva were slightly cyanotic. Toward evening 
the heart seemed weaker; the animal swallowed a little milk; it had 
passed very little urine, and the little that was passed was of a dark 
color. The cause of the color of this urine has not been determined; 
it was not hematoporphyrin, by the spectroscopic test. 
December 14 — The animal was found dead. It died sometime after 11 
p. m. of the preceding day. A post-mortem examination showed the 
following: lungs, hypostatic congestion of the left lobe; liver, congested 
and dark brown in color; esophagus and stomach, containing a little clear 
mucous substance: all other organs normal. 
DOG XI (FEMALE) 
Weight of dog, ? (small, about 8 kilograms). 
January 5, 1917 — Dog fumigated at 20° C. for a period of three hours. 
Time when fumigation was begun, 2.25 p. m. 
Time when fumigation was finished, 5.25 p. m. 
