PHYSIOLOGICAL ACTION OF NITROBENZENE VAPOR ON ANIMALS 447 
Observations: The animal lay down and remained quiet for about 
three hours, and then became restless for a time but soon became quiet 
again. When first removed from the tank the animal appeared well and 
started to walk away, but lost control of its hind legs and tumbled about 
for a moment, then became excited. It vomited (chunks of meat which 
had not started to digest), and then lay prostrate for about one-half hour. 
The lips and the tongue were cyanotic; the pupils were dilated and did 
not react to light. The animal’s condition improved shortly and it again 
appeared well. On the following morning a quantity of sticky, bloody 
feces was found in the animal’s cage; no further symptoms of poisoning 
had developed, however, nor did any symptoms appear during the next 
four days. At the end of this time the cat was found dead. 
CAT XVIII 
October 5, 1917 — Cat fumigated at 22.5° C. for a period of three hours. 
Time when fumigation was begun, 9 a. m. 
Time when fumigation was finished, 12 m. 
Observations: The animal remained quiet during the fumigation and 
was removed from the tank apparently unharmed, but became slightly 
stupid toward evening. A sample of blood was taken and examined. 
It was dark brown and showed methemoglobin by spectroscopic 
analysis. 
October 6 — The animal was found with well-advanced symptoms of nitro- 
benzene poisoning — nystagmus, paralysis of the muscles of the hind 
legs, and periods of excitation followed by prostration. The cat refused 
milk, nor was it possible to place any in its mouth. A sample of blood 
drawn from the ear was coffee-colored and showed the same spectrum 
as on the preceding day. 
October 7 — The condition of the animal remained about the same. It 
lay on its side entirely helpless and apparently unconscious. 
October 8 — The condition gradually grew worse and the animal died 
toward evening. A post-mortem examination showed a pronounced 
congestion of lings and viscera, and the blood vessels of the neck were 
turgid with blood. 
