462 WALLACE LARKIN CHANDLER 
off their heads. The cerebellum was hurriedly dissected out and small 
sections from different parts were placed directly into the fixing fluid. 
The remainder of the technique was the same as that employed in the 
case of the dogs. The same degenerative changes in the Purkinje cells 
were found as were found in the case of the dogs. The Purkinje cells 
from the control bird were normal. 
Two chickens, poisoned and killed in the same manner, showed the 
same type of degeneration in the Purkinje cells as is described above, 
while the cells from the control bird, stained and mounted on the same 
slide with those from the poisoned bird, were apparently normal. 
THE SYMPTOM COMPLEX OF NITROBENZENE POISONING 
Unlike Letheby and Filehne, the writer has been unable to divide 
the symptom complex of nitrobenzene poisoning into two types — that 
accompanying a rapid action of the drug, and that accompanying a retarded 
action. As a matter of fact, the symptoms are never sufficiently uniform 
in any case, whether the action is slow or rapid, to permit of classification 
into types. There is a probability, however, that the symptom complex 
may be somewhat different in widely separated groups of animals; but 
this can be determined only by a summation of all the symptoms observed 
in experiments on a large number of individuals from each group. 
So far as has been observed by the writer, the dominant symptom in 
frogs and in insects is a general depression, tho in insects a tremulous 
movement of the legs has also been observed. In birds and mammals, 
one or more or all of the following symptoms may appear in acute cases 
of poisoning by the vapor of nitrobenzene: cyanosis, nausea, vomiting, 
ataxia, asynergia (distinguished from other types of cerebellar ataxia 
in that there appears a retro- or propulsion in an antero-posterior plane 
instead of a lateral, the legs appearing as if either running away from the 
body and throwing the animal backward, or failing to keep up with the 
body and throwing the animal on its head), impairment of digestive 
functions, nystagmus, equal or unequal dilation or contraction of the 
pupils, irritability, tenderness of the occiput (headache), unconsciousness, 
hallucinations, adiadochokinesis, slowing of the pulse rate, irregular and 
weakened respiration, palpitation of the muscles, rapid (running) move- 
ments of the legs, rotation of the head and neck describing broad circles, 
rotation of the body around its longitudinal axis, asthenia, and the nitro- 
