26 STRONG AND TEAGUE. 



in regard to the final result of the experiments to be made. In more recent 

 work, performed during the past year, these authors state that antimony is as 

 valuable as arsenic in the treatment of trypanosomiasis. 



Mesnil and Brimont experimented with potassium antimonyl tartrate in rats 

 and found that the drug caused the disappearance of the parasites from the 

 circulation in about two hours after the injection, but that in many eases they 

 reappeared in the blood. The animals infected with some, but not all, of the 

 species of trypanosomata were cured by this drug. 



Boyce and Breinl, however, did not find sodium antimonyl tartrate to give 

 good results either in infected rats or horses. One horse and one monkey were 

 treated with this drug, both eventually succumbed to the disease. 



Mesnil and Brimont found in further experiments on mice, that when the 

 animals were treated with tartar emetic, relapses usually occurred, although in 

 the case of the trypanosomata of surra and dourine the parasites disappeared for a 

 time after a single injection of the antimony compound. 



Laveran also found tartar emetic unsatisfactory, and sulphide of antimony 

 less active than sulphide of arsenic (orpiment). 



Uhlenhuth and Woithe treated 27 rats with sodium antimonyl tartrate. 

 Their results were very discouraging. Repeated injections did not even cause 

 temporary disappearance of the parasites. 



Manson has reported the unsatisfactory treatment of one case of sleeping 

 sickness with this drug. 



Broden and Rodham have used soluble as well as insoluble compounds of 

 antimony in cases of sleeping sickness. The hypodermic injections were followed 

 by great irritation and pain so that the drug was given intravenously. Seven 

 hundredths of a gram sometimes caused the disappearance of the parasites from 

 the blood, but they frequently reappeared after a short time. After repeated 

 injections the patients usually lost appetite and complained of malaise. They 

 regard the antimony compounds as about of equal value with atoxyl. 



Hodges states that the treatment both with antimony cream and with tartar 

 emetic, singly, has been unsuccessful; that these drugs do not seem to be effective 

 for any length of time and that the treatment of patients with antimony compounds 

 had been discontinued in Uganda at the time the report was made. 



Breinl and Nierenstein attempted to prepare an organic antimony compound 

 analogous to atoxyl. After many trials they succeeded in making para, meta 

 and ortho aminophenyl stibinic acids. The ortho compound was impracticable 

 and the meta was unsatisfactory. Extensive experiments with the para compound 

 showed it to be a fairly powerful trypanocide, although not so rapid in its action 

 as sodium antimonyl tartrate. It was less likely to cause abscesses on injection. 

 The authors advise a careful, systematic examination of the urine in the cases 

 treated because of the danger of the production of kidney lesions. 



Kopke has treated a few cases of sleeping sickness resistant to atoxyl, with 

 this drug. The injections seemed to cause the disappearance of the parasites, 

 although the author states the inoculations were far too painful for general use. 



Laveran has recently suggested the use of an aniline compound of antimony. 

 In potassium antimonyl tartrate potassium was replaced by the aniline radical. 

 Several experiments on guinea pigs seemed to show that the drug was superior to 

 the potassium salt of antimony. A few injections had been made in natives of 

 Senegal, but no final results have been reported. 



In the further treatment of sleeping sickness, neither Martin and Rigenbach 

 nor Broden and Rodhain have found tartar emetic administered alone of any 

 great value; the action of the drug after injection is marked, but, as a rule, is 

 only temporary. 



