TREATMENT OF TRYPANOSOMIASIS. 29 



Broden and Rodham found that the combined treatment with atoxyl and bi- 

 chloride of mercury did not prove itself at all superior to that with atoxyl alone. 



Breinl employed aeetj'lated atoxyl, sublimate and Donovan's solution, in 6 

 monkeys. Five out of the (i animals were alive and free from parasites at the 

 time the report was made. 



Hodges states that the results of the treatment of sleeping sickness with 

 atoxyl and bichloride of mercury do not, at present, promise to be of a more 

 permanent nature than do those with atoxyl alone. 



TREATMENT WITH ATOXYL AND ANTIMONY. 



Broden and Rodhain, and Martin and Darne, in the treatment of sleeping 

 sickness, combined atoxyl with injections of the soluble antimony compounds 

 with very encouraging results in early eases of the disease. 



Hodges states that in man, treatment by atoxyl and antimony has not at 

 present shown favorable results in Uganda, although these remedies in combina- 

 tion and alternation are being more extensively tried. 



Rennes treated one horse infected with dourine with atoxyl combined with 

 antimony. Two months afterwards the blood of the animal was free from 

 parasites. Six months after the beginning of the treatment, the horse was appar- 

 ently well. He was then reinoeulated and contracted a new infection. 



Martin, Leboeuf and Rigenbach believe that atoxyl given with tartar emetic 

 is more poisonous than when given alone, but that the combination is the most 

 effective treatment for trypanosomiasis they have tried. The antimony compound 

 was given intravenously in doses not greater than 10 centigrams of a 1 per cent 

 solution. They treated 31 cases of sleeping sickness with the combination of 

 atoxyl and the antimony compound. Only one of these was in the first stage ot 

 the disease. Of the 31, at the time of the report, 10 were dead, 11 had abandoned 

 treatment and 10 were still under observation; 7 of these had parasites in their 

 blood. The authors finally conclude that while the combination of atoxyl and 

 tartar emetic is capable of giving excellent results in early cases, it does not suc- 

 ceed in those which have entered the second stage of the disease. 



TREATMENT WITH ARSENOPHENYLGLYCIN. 



Through the courtesy of Prof. Paul Ehrlich, of Frankfort, who very 

 kindly offered to send us new preparations made in his laboratory and 

 which seemed of most value in the treatment of trypanosomiasis, for 

 further experimentation in the treatment of larger animals and for a 

 demonstration of their practical efficiency, a shipment of arsaeetin was 

 first received and, in the beginning of the year 1909, a shipment of 

 arsenophenylglycin. Professor Ehrlich has continued to supply us with 

 repeated shipments of arsenophenylglycin and all of our experiments 

 with this drug have been carried on with the compound prepared and sent 

 from his laboratory. We take this opportunity of expressing our grati- 

 tude to Professor Ehrlich for having given us the opportunity to study 

 carefully the effect of this, preparation and for so generously supplying 

 us with the drug. 



Arsenophenylglycin is a light yellow powder, very soluble in water 



