50 



STRONG AND TEAGUE. 



Webee & Krause. Berliner kiln. Wchnsch. (1907) 44, 192. 



Wendelstadt. Verhandlungen des deutschen Kolonialeongress, Berlin, 1905, 1900, 



287; Berliner klin. Wchnsch. (1908) 45, 192. 

 Wendelstadt & Fellmer. Ztschr. f. Hyg. u. Infectionskrankh. (1906) 52, 263; 



Deutsche, med. Wchnsch. (1904) 47, 1711. 

 Wenyon. Journ. Hyg. (1907) 7, 273. 



Yakimoff. C'entralb. f. Bakt. etc., Orig. (1908) 45, 437. 

 Zupitzka. Beriehte der Schlafkrankheitskommission in Togo iiber die Zeit von 



1 April bis 30 Jimi, 1909. Reference Sleeping Sickness Bulletin (1909) 12. 



Table I. — Dosage of arsenophenylglycin in normal monkeys. 



Weight 

 of mon- 

 key in 

 grams. 



Dose of 

 arseno- 

 phenyl- 

 glycin in 

 grams per 

 kilo. 



Death 

 after— 



Weight 

 of mon- 

 key in 

 grams. 



Dose of 

 arseno- 

 phenyl- 

 glycin in 

 grams per 

 kilo. 



Death 

 after— 



Weight 

 of mon- 

 key in 

 grams. 



Dose of 

 arseno- 

 phenyl- 

 glycin in 

 grams per 

 kilo. 



Death 

 after— 



2,250 

 1,800 

 2,350 

 2,300 

 2.300 

 2,320 

 1.900 

 2,440 

 2,300 



0.10 

 0.10 

 0.12 

 0.12 

 0.14 

 0.14 



o. ic 



0.16 

 0.18 





2,100 

 2,350 

 2.170 

 2,820 

 2,700 

 2, 620 

 2,350 

 2,300 

 2,400 



0.18 

 0.20 

 0.20 

 0.22 

 0.22 

 0.24 

 0.24 

 0.26 

 0.26 





1,520 

 1,440 

 2.170 

 2,040 

 2,370 

 1,970 

 1,730 

 1,750 



0.26 

 0.28 

 0.30 

 0.30 

 0.32 

 0.32 

 0.34 

 0.36 



3 days. 











3 days. 

 8 days. 

 3 days. 

 2 days. . 

 10 days. 

 2 days. 



— 







6 days. 















3 days. 





Table II, Series I (Monkeys) 



No. of 

 monkey. 



Weight 



in 

 grams. 



First 

 treat- 

 ment in 

 grams per 

 kilo. 



Interval be- 

 tween doses. 



Second 

 treat- 

 ment in 

 grams per 

 kilo. 



Result. 



Period free 

 from trypa- 

 nosomata. 



Days. 



Blood 

 exami- 

 nation. 



4477— 



4432. 



4332.... 



4473 



4479 



4341. 



4472. 



4476— 

 4421— _ 



4293. 



4474- 



4480- 



4337. 



4475 



4481 



4419 



4420 



4350- 



4478- 



4422. 



2,500 

 850 

 1,620 

 3,200 

 1,100 

 1,520 

 5,250 

 1,950 

 1,220 



. 0.04 

 0.04 

 0.04 

 0.05 

 0.05 

 0.05 

 0.06 

 0.06 

 0.06 



18 

 28 



Pos. 

 Pos. 



0.08 

 0.08 





7 months. 

 2* months." 



7 months. 



8| months. 

 Do. 



Do. 



Do. 



6 months. 



Died in 8 days (negative) 



20 

 34 



Pos. 

 Pos. 



0.08 

 0.08 







27 

 19 



Pos. 

 Pos. 



COS 

 0.08 















5,900 

 1,550 

 1,770 

 3,950 

 1,600 

 1,200 



750 

 1,900 

 2,500 



850 



0.07 

 0.07 

 0.07 

 0.08 

 0.08 

 0.08 

 0.09 

 0.09 









Alive _ 



do 









34 



Pos. 



0.09 



Died in 19 davs (negative) -— _ 









do 



23 

 51 



Pos. 

 Pos. 



0.10 

 0.10 



do 



Died in 3 hours 



Died in 17 davs (negative) - __ 

 Died 17 days after inoculation- 

 Died 14 days after inoculation.. 





















• This monkey died 10 days after a third treatment with a dose of 0. 15 gram per kilo. 



