294 BOWMAN. 



shows large quantity of albumin. May 19 : Six-tenths of a gram of arsenophenyl- 

 glycin given. Eosinophiles had increased to 5 per cent. May 24: Numerous 

 crescents found and no young forms. After the last injection May 19 the tem- 

 perature remained low until the patient left the hospital, but parasites were 

 always present. 



Case III. — Tertian malaria. Filipino man. Complaint: Chills and fever for 

 a month at first every third day, but now every day. Headache severe, and 

 occasionally the patient says he becomes dizzy and loses consciousness. He appears 

 extremely pale and anaemic. A hsemic murmur is heard at the base of the 

 heart. The spleen is not enlarged and otherwise the general physical examination 

 is negative. A blood-smear shows numerous half-grown tertian parasites. 



May 20: A blood-smear is the same as above. Six-tenths of a gram of arseno- 

 phenylglycin given. May 27 : No change in blood picture. May 2S : Six-tenths 

 of a gram of arsenophenylglycin given. May 30 : A f ew half-grown forms. June 

 7: Severe local reaction at the site of the last injection. Later, an abscess devel- 

 oped which proved to be sterile. 



Case IV. — jEstivo-auliimnal malaria. Filipino man. Complaint: Chills and 

 fever. Present illness has continued for three months with chills and fever 

 two or three times a week and pains in the legs, bones and joints. The patient 

 is very pale and weak. A soft and blowing murmur is heard at the point of 

 maximum impulse. The spleen is enlarged 1 centimeter below the costal border. 



May 27: A blood-smear shows young amoeboid forms and also nearly full-grown 

 aestivo-autumnal parasites. No crescents seen. May 2S: Six-tenths of a gram of 

 arsenophenylglycin given. May 29 : No changes in the blood picture. May 30 : 

 A few crescents found and very few young forms. Six-tenths of a gram of arseno- 

 phenylglycin given. June 12: A blood-smear shows numerous crescents, no" young 

 forms. The patient has gained in weight and feels perfectly well. When he 

 entered the hospital much albumin was found in the urine. At the time of 

 discharge no albumin Mas present. 



Case V. — /Est iro-aul am mil malaria. Filipino man. Complaint: Chills and 

 fever. Typical symptoms of malaria. The spleen is enlarged 10 centimeters below 

 the costal margin; it is movable and soft. 



May 20 : Young intracorporeal forms and crescents present in a blood-smear. 

 May 2G: Crescents and young amoeboid forms. Six-tenths of a gram of arseno- 

 phenylglycin given, the patient's temperature being 40° at the time of injection. 

 The temperature dropped, but rose again on June 1, when 1 cubic centimeter 

 of a solution of hydrochloride of quinine was given and then 0.G2 gram three 

 times a day until the patient was discharged on June 16, on which date a blood- 

 smear showed a few crescents but no other forms of the parasite. 



Case VI. — Tertian malaria. Filipino man. Complaint: Chills and dysentery. 

 The patient is extremely pale, tongue coated and breath foul. A general physical 

 examination shows nothing of importance except an enlarged liver, 3 centimeters 

 below the costal border. The spleen is not enlarged. 



May 28: Numerous tertian parasites found in the blood. May 30: Parasites 

 found in a blood-smear. June 2: Six-tenths of a gram of arsenophenylglycin 

 given. June 7 : Marked local reaction at the site of injection. A blood-smear 

 was negative. June 10: The abscess opened and drained. No organisms were 

 seen in a stained smear and no odor is present. June 19: Blood examined after 

 a slight rise in temperature, and parasites found. 



Case VII. — Subtertian (malignant) malaria. Filipino man. The patient is 

 in a semiconscious condition and will not answer questions. He is extremely 

 anemic: the liver is not enlarged and the spleen is not palpable. A blood-smear 



