296 BOWMAN. 



In some cases of ajstivo-auturnnal infection the young forms of the 

 parasites seemed to disappear after injection of the drug, but in all 

 instances the crescents were not affected. 



No definite effect was noted in the three cases of tertian malaria, 

 parasites being found in each, at some period after the injections of 

 arsenophenylglycin. No effect was produced in the case of quartan 

 malaria. 



Severe abscesses resulted from the injections in five cases. All were 

 sterile, no growth occurring when the pus was transferred to culture 

 media. 



The effect of the drug on the kidneys was practically negative. Case 

 II showed some increase in the amount of albumin after treatment. 

 On the other hand, the albuminuria disappeared in Case IV after 

 treatment with arsenophenylglycin. 



CONCLUSIONS. 



1. Splenomegaly is by no means a constant symptom of malaria. 



2. Chronic nephritis is a common sequel of recurring attacks of 

 malarial fever. 



3. Peripheral neuritis and many of the cases diagnosed as beriberi 

 may be attributed to frequent previous attacks of malaria. 



4. Treatment with arsenophenylglycin produces no definite effect on 

 the life of the malarial parasite, and has seemingly no effect on the 

 crescent body. 



5. An overdose of arsenophenylglycin may produce the symptoms of 

 arsenical poisoning. 



One case of filariasis was also treated with arsenophenylglycin. The patient's 

 blood was examined at intervals of four hours for twenty-four hours; at 1.30 

 p. m. no embryos were found in three drops, but at 5 a. m. 50 motile organisms 

 were present. 



In all, 3 grams of arsenophenylglycin were given to this patient, who also 

 developed symptoms of arsenical poisoning, with an erythematous rash which 

 later went on to the stage of desquamation. 



The filarial embryos were unaffected, 65 being counted in three drops of 

 blood after the treatment. 



