370 



SELLARDS. 



found in cases treated with chloride, bicarbonate and acetate of sodium. 



N 

 The estimations were made by titration with —^r sodium hydroxide, 



with phenolphthalein as an indicator, according to the recommenda- 

 tions of Nsegeli (8). For convenience, the data are expressed in 

 fractions of a normal solution. 



Table IV. — Showing maximum acidity of urine in fractions of a normal solution 

 after intravenous injection. 



Sodium 

 chloride, 

 maximum 



acidity 

 of urine. 



Sodium acetate. 



Sodium bicarbonate. 



Amount, 

 in grams. 



Maximum 



acidity 



of urine. 



Amount, 

 in grams 



Maximum 

 acidity 

 of urine. 



A 

 ,', 

 A 

 A 

 A 

 A 

 A 

 A 

 A 

 ,',-, 

 A 

 A 

 A 



60 

 15 

 60 

 40 

 80 

 80 

 40 

 80 

 80 

 40 

 60 

 60 

 40 



A 



liij 



A 



A 



1 



10 



1 7 

 fa 



A 



A 



40 

 35 

 70 

 80 

 60 

 40 

 40 

 60 

 60 

 90 

 30 

 30 

 30 



A 

 A 



1 

 2(1 



A 

 A 

 A 

 A 

 A 

 A 

 A 

 A 

 A 

 A 



GENERAL AVERAGE. 



A 





■A 



1 





1 * I 



In the preceding table, it is seen that high and low values occur 

 in all three groups of cases. The normal range as stated by Nsegeli 

 varies from one one-hundredth to one-thirtieth ; in the sodium chloride 

 group there are several instances where the concentration is higher 

 than one-thirtieth normal. The general averages which have been cal- 

 culated have relatively little significance since many of the cases had 

 received almost sufficient acetate or alkali to neutralize the urine. 

 However, the behavior of the individual cases showed definitely that, 

 within certain limits, the injection of bicarbonate or acetate was fol- 

 lowed by an increase in acidity of the urine. The first or second 

 specimen voided after injection often showed a normal degree of acidity, 

 but the latter increased rapidly, usually reaching its maximum during 

 the first twenty-four hours after secretion commenced. The decline to 

 normal took place gradually, requiring two or three days. The cause 

 of the increased acidity following the injection of alkali was not deter- 

 mined. One possible factor might be found in the sudden diminution 

 of the albumen content of the urine, which sometimes occurred in cases 



