386 



SELLARDS. 



SUPPRESSION OP UEEA. 



After secretion of the urine was established, determinations of the 

 urea content showed a suppression of urea somewhat comparable to the 

 suppression of urine. In the following table, the determinations were 

 made by the sodium hypobroniite method and therefore include the 

 ammonium salts as well as the urea. The analyses were at first made 

 on twenty-four hour specimens of urine, but, after a marked suppression 

 of urine, a sudden increase in the urea content frequently occurred such 

 as would be overlooked in estimations of the total urea excreted per day. 

 For example, the first 100 cubic centimeters of urine voided after a 

 period of suppression might contain only 0.3 per cent of urea. For the 

 remaining twenty-four hours, perhaps a liter of normal urine might be 

 voided. It was necessary to examine each successive specimen separately 

 in order to detect these critical changes. 7 



The percentage of urea, apparently, was almost independent of the 

 quantity of urine which was voided, and, at least as shown by Table IX, 

 the sudden increase in percentage was not due to a diminution in the 

 volume excreted, but was rather accompanied by an increase in volume. 

 The changes in the urea content did not consist in fluctuations from small 

 to large amounts, but the increased outputs were maintained. 



Table IX. — Showing changes in excretion of wea. 



Serial 

 num- 

 ber. 



Treatment. 



First 

 day. 



Second 

 day. 



Third 

 day. 



Fourth 

 day. 



Fifth 

 day. 



Sixth 

 day. 



9. 



12 

 13 

 1ft 

 22 





Per cent. 

 0.4 

 2.8 

 0.4 

 1.0 







Per cent. 

 0.5 



Per cent. 

 0.4 

 3.5 

 1.1 



Per cent. 



Per cent. 

 1.2 



Per cent. 



do 



do 



do 



do 







0.35 



1.8 



0.2 



0.25 



0.75 



1.6 



2.4 







0.3 

 0.6 

 1.5 



0.25 

 0.5 



0.5 



0.3 



53 



do 



0.1 

 0.05 



52.— 



Sodium bicarbonate, 30 

 grams. 













7 The accurate collection of an extensive series of specimens in the midst of an 

 epidemic was made feasible by the very excellent supervision of Miss A. E. 

 McEvoy, Mrs. K. E. Taulbee, and Miss B. M. Gertsch, the nursing staff ijf San 

 Lazaro Hospital. 



