444 STRONG. 



in outline, sharply circumscribed, some as small as 3 millimeters, but generally 

 4 or 5 centimeters in diameter. They are usually covered with yellow crusts, 

 although in some instances they show reddened summits. They are usually raised 

 about 0.5 centimeter above the surrounding surface of the skin. There are many 

 pigmented spots on the anterior surface of the thighs, which are evidently the 

 result of healed lesions. (For the distribution and character of the lesions see 

 Plate X, figs. 1 and 2.) The patient was given 0.3 gram of the preparation 

 in the usual manner. When seen twenty days later, the lesions had entirely 

 disappeared, the skin was everywhere entirely smooth, only pigmented patches 

 remained where the lesions had previously existed (see Plate X, figs. 3 and 4). 

 He since has remained well. 



Case XV. — (Plate XI.) Nicomedes; age 8 years. The lesions are situated 

 over the left eyebrow, chin, about the left shoulder, the arms, bends of the 

 elbows, left forearm, knees, legs, left ankle, and posteriorly over the buttocks, 

 gluteal fold, thighs and legs. There is a superficial ulcer measuring about 4 

 centimeters in diameter over the right heel. The lesions consist of granulomatous 

 tumors measuring about 3 millimeters to 3 centimeters in diameter. They are 

 sharply circumscribed, and raised about 4 or 5 millimeters above the surrounding 

 skin. Many of them are covered with yellow crusts. Some of the smaller lesions 

 appear as reddened papules, others as mushroom-like granulomatous masses. 

 For their distribution and character see Plate XI, figs. 1 and 2. The patient 

 was given 0.3 gram of the preparation in the usual manner. Twenty days 

 afterwards the lesions had practically entirely disappeared (see Plate XI, figs. 

 3 and 4). He since has been well with the exception of having contracted a 

 severe case of scabies, in some of the lesions of which SarcopUis scabei was found. 

 No urticarial eruption followed the injection. 



Case XVI. — (Plate XII.) Felix; age 12 years; duration of the disease 8 

 years (?). The lesions are situated anteriorly over the chin, neck, left axilla, 

 on the right arm, below the right axilla, the bends of the elbows, above the 

 knees, the left foot, over the fourth and little toe, and posteriorly over the neck, 

 shoulders, back, elbows, forearms, buttocks, above the popliteal spaces, legs and 

 right ankle. The lesions consist of papillary granulomatous tumors varying 

 from 4 millimeters to 3 centimeters in diameter, round or irregular in outline, 

 and raised about 5 millimeters above the surrounding skin. They are usually 

 covered with yellow crusts, or when not so covered they are red in color. Small 

 blood vessels may be seen traversing these as a net work. Numerous pigmented 

 spots are present over the knees, legs, ankles and buttocks, the result of older 

 lesions. On the fourth toe of the left foot there is an ulcerating granulomatous 

 lesion. For the distribution and character of the lesions see Plate XII, figs. 



1 and 2. The patient was given 0.3 gram of the preparation in the usual manner. 

 Twenty days later the lesions had entirely healed, the skin was everywhere 

 smooth, only very slightly reddened areas of skin remained where they had 

 previously existed (see Plate XII, figs. 3 and 4). The patient since has remained 

 entirely well. 



Case XVII. — Esteban; age 12 years; duration of the disease one year. The 

 lesions consist of papillary granulomata situated anteriorly over the shoulders, 

 bend of the left elbow, and posteriorly over the left elbow. They measure about 



2 to 3 centimeters in diameter, and are raised above the surrounding tissue. 

 Over the right heel is a partially ulcerated granulomatous lesion measuring 

 about 3 centimeters in diameter. There are numerous scars over the chest, which 

 are the result of old lesions. The patient was given 0.3 of a gram of the 

 preparation in the usual manner. When seen twenty days after the injection 



