THE SPECIFIC CURE OP YAWS. 445 



the lesions had entirely disappeared, and the skin was everywhere entirely 

 smooth. He since has remained well. 



Case XYIII. — Juan; age 8 years; duration of disease 4 months. There is an 

 ulcerating granuloma measuring about 3 centimeters in diameter situated over the 

 anterior surface of the right leg. Over the left leg, posteriorly, there are five 

 granulomatous lesions measuring 5 millimeters to 1 centimeter in diameter, covered 

 by yellow crusts. There are numerous scars over both legs which are the result 

 of earlier lesions. The patient was given 0.3 gram of the preparation in the 

 usual manner. Twenty days later all signs of the lesions had disappeared, the 

 skin was entirely smooth. He since has remained well. 



Case XIX. — (Plate XIII.) Francisco; age 24 j r ears; duration of the disease 

 7 months. He is unmarried, and has never had syphilis. No scar on the penis. 

 The lesions are situated anteriorly over the neck, shoulders, chest, abdomen, 

 arms, forearms, and thighs, and posteriorly over the neck, shoulders, back, arms, 

 buttocks and legs. The lesions consist of numerous small pappillomata measur- 

 ing from 2 to 4 millimeters in diameter, sharply circumscribed, and raised from 

 3 to 4 millimeters above the surrounding skin. Some of the larger ones are 

 covered with yellow crusts. For distribution and character of the lesions see 

 Plate XIII, figures 1 and 2. The patient was given 0.4 gram of the preparation 

 in the usual manner. Fifteen days after the inoculation the skin was perfectly 

 clear and smooth (see Plate XIII, figures 3 and 4). He since has remained well. 



Case XX. — Tiburcio; age 10 years; duration of the disease is stated to be 

 one month. Evidently yaws has been present for a longer time. The lesions 

 are situated anteriorly over the right ehest, below the clavicle, left breast 

 below the nipple, both forearms, scrotum, left thigh, above the right knee, and 

 posteriorly over the forearms, left buttock, both thighs, legs, and left ankle. 

 The lesions consist of granulomatous tumors measuring usually about 1 to 3 

 centimeters in diameter, sharply circumscribed, round or irregular in outline, 

 and raised for a distance of about 4 or 5 millimeters above the surrounding 

 skin. Many of them are covered with yellow crusts; in the case of others they 

 are red in color and the surface uneven. The patient was given 0.3 gram of 

 the preparation in the usual manner. After twenty days the skin was entirely 

 clear and smooth. He since has remained well. 



Case XXI. — Maximo ; age 5 years ; duration of the disease 5* months. The 

 lesions are situated about the mouth, on the upper and lower lips, on the chin 

 and neck, in the left axilla, and on the posterior surface of the scrotum. They 

 consist of granulomatous tumors measuring from 6 to 10 millimeters in diameter, 

 and raised from 3 to 5 millimeters above the surrounding skin. The patient was 

 given 0.25 gram of the preparation in the usual manner. After nine days the 

 lesions had completely disappeared and the skin was perfectly smooth. He since 

 has remained well. 



Case XXII. — Ling (Chinaman) ; age 35 years. The lesions consist of five gran- 

 ulomata measuring from 1 to 1.5 centimeters in diameter, situated on the left 

 leg and above the left knee. There is also an ulcerating granuloma measuring 

 about 2 centimeters in diameter on the left ankle. A smear from one of these 

 granulomata shows numerous spirochetal. The patient was given 0.45 gram of 

 the preparation in the buttocks. After three weeks the granulomatous lesions 

 had entirely disappeared and the ulcer entirely healed. He since has remained 

 well. 



Case XXIII. — Pedro; age. 18 years; duration of the disease 4 months. The 

 lesions are situated anteriorly over the forehead, cheeks and chin, the chest, 

 shoulders, arms, and forearms, thighs and legs ; posteriorly over the shoulders, 



