456 DUDLEY AND WHITMORE. 



deaths from hydrophobia in the Philippines since about October 1, 

 1902. Thirty-one of the thirty-nine provinces in the Philippines, to 

 which must be added the Island of Mindanao (Moro Province) and the 

 district of Manila, have reported deaths from hydrophobia. Many of 

 these reports so accurately describe rabies that they can hardly refer to 

 any other disease. 



However, none of these cases had been proved to be rabies. Ac- 

 cordingly, we decided to take up the study of the problem and determine, 

 if possible, whether rabies actually does exist in this Archipelago. On 

 April 1, 1910, we mailed a circular letter to all the physicians in the 

 Philippines, asking them to send us the heads or brains of animals killed 

 for, or dead of, suspected rabies ; the material to be sent packed in ice, or 

 in 50 per cent glycerine where ice was not available. We requested also 

 that they report any cases of human rabies to us, so that if possible we 

 might see the jiatients. 



In response to this circular, Dr. Salvador Gomez, of Angeles, Pam- 

 panga Province, sent us the bodies of two dogs on April 16, 1910. These 

 two animals had been bitten by a suspected rabid dog on March 22, and 

 their owner, recognizing the danger of rabies, kept them tied from 

 that date. 4 



One of these dogs became sick on April 10, the other on April 14. 

 They refused to eat, saliva dribbled from their mouths, and they showed 

 a tendency to snap and bite at everything. One of them escaped one day, 

 and after running about bit two other dogs and a pig. On the following 

 day another of the dogs escaped and attacked its mate, and the two 

 animals fought viciously. The owner then killed both in the way usual 

 among the natives, namely, by striking them over the head with a club. 

 A few hours afterwards Doctor Gomez learned of the incident, secured the 

 bodies and sent them to us. 



The animals had been dead about forty-eight hours when we received 

 them and no ice had been available for packing them for shipment. The 

 skull of one (number 2) had been crushed by the blow that killed it, and 

 the brain cavity was filled. with a mass of blood clots, brain tissue, and 

 bone fragments. "We succeeded in demonstrating Negri bodies in the 

 brain tissue of both of these animals; in the hippocampus and cerebral 

 cortex of dog number 1 and in a piece of the cerebellum of dog number 

 2. The bodies stained rather faintly and it was difficult to bring out the 

 "inner bodies" because of the length of time which had elapsed since the 

 death of the animals and the beginning of putrefaction of the brain 

 tissue. 



* The natives throughout the Islands understand that a dog bitten by another 

 is likely to die, and that a person bitten by such a clog will probably die. So, 

 when a dog is bitten it is always killed or tied up. 



