HYDROPHOBIA IN THE PHILIPPINES. 457 



An emulsion of the brain tissue from each dog was injected intramus- 

 cularly into five rabbits. Eats were not available for inoculation. The 

 brain tissue of dog number 2 killed all rabbits within eighteen hours,, 

 because of the contamination which was present. All rabbits inoculated 

 with the emulsion of brain tissue from dog number 1 died within from 

 fifteen to twenty da}'s with the symptoms of rabies, and we were able to 

 demonstrate Negri bodies and Lentz passage bodies in the brains of these 

 rabbits." (See PL I.) This strain of virus was carried through seven 

 passages in rabbits between April 17 and July 9, and at the end of that 

 time it regularly killed rabbits with typical rabies in nine days when 

 inoculated subdurally. We did not attempt to demonstrate Negri bodies 

 or Lentz passage bodies in the brains of rabbits beyond the third passage. 

 It was not considered necessary to carry this strain further and so no 

 more inoculations were made, the strain being preserved in neutral 

 glycerine in the refrigerator. 



On May 29, Dr. Ambrosio Eeyes invited us to see a case of human 

 rabies under his care here in Manila, 



The patient, a little boy S years old, while playing on April 5 with other 

 chili lieu in a street near his home, was bitten on the left forearm by a strange 

 dog that ran in among the children. The wounds were cauterized with carbolic 

 acid and they healed in eight days. On May 27, vesicles were noted over the site 

 of the bite. This herpetic eruption traveled up the forearm and arm, over the 

 left pectoral and left scapular regions, and finally up onto, and behind, the left 

 ear. The lesions itched intensely and the boy scratched them, leaving an abraded 

 surface from which a thin, clear serum exuded. In the afternoon and evening of 

 May 27, the boy became drowsy and did not care to play. The next morning 

 there was difficulty in swallowing, and the parents, recognizing that the boy was 

 developing rabies, called Doctor Eeyes. On May 29 the boy was unable to 

 swallow. Water taken into the mouth caused a spasm in his throat and he im- 

 mediately spat the water out. There was almost complete suppression of urine. 

 On May 30 the sight of water or food would provoke a severe spasm and the boy 

 died in a convulsion on the evening of May 30. 



The case clinically was one of typical rabies, and Doctor Eeyes 

 recognized it as such on May 28. He informed us that this is the 

 eighth case of human rabies he had seen in a private practice of twenty 

 years in Manila, Prom his early and accurate diagnosis in this case, 

 there is every reason to believe that all of his other seven cases were 

 rabies. 



Negri bodies were not found in the brain of this boy, but an emulsion 

 of the brain injected subdurally and intramuscularly into rabbits killed 

 all of them with typical rabies in from fourteen to twenty days. Negri 

 bodies and Lentz passage bodies were readily demonstrated in the brains 



5 Dudley and Whitmore : Rabies in the Philippines. A Preliminary Report, 

 read before the Manila Medical Society, May 2, 1910. Bull. Manila Med. Soc. 

 (1910), 2, 99. 



