TREATMENT OF STRYCHNINE POISONING. # 549 



9.13: Chloroform 3/6 and trachea compressed closer to tracheal catheter by 

 gentle outside pressure keeps the dog sufficiently anaesthetized for operation. 



9.20: Pulse 66, full, fairly strong, drops a beat occasionally. 



9.52: Pulse 60, full, strong, regular. Respiration 21, deep; expiration pro- 

 longed, and forcible. The pinching of the toe produces slight reflex. Pupils the 

 size of pinhead. 



9.56 : Gently compressing trachea more closely on tracheal catheter increases 

 percentage of chloroform sufficiently to abolish reflex from the pinching of the 

 toe. Lid reflex sharp. 



9.58: 0.83 cubic centimeter strychnine sulphate (1 per cent aqueous solution) 

 injected slowly into femoral vein along with Ringer-Locke solution. 



9.59.5: Violent tetanus with rigidity of respiratory muscles and cessation of 

 respiration. Thoracic massage and insufflation of dilute chloroform vapor main- 

 tained life and reduced the convulsion. 



10.20: Chloroform 2/6+; voluntary movement; voluntary respiration; pre- 

 monitory symptoms of convulsion. 



10.21 : Chloroform 4/6. 



10.23: Chloroform 3/6 — Ringer solution increased in rate. 



10.27 : Chloroform 3/6 — Ringer solution increased in rate. 



10.29 : Chloroform 3/6 — insufflation stopped. Compression of trachea onto ca- 

 theter increases percentage of chloroform sufficiently to stop respiration. 



10.35: Chloroform 2/6 — insufflation. 



10.45: Voluntary respiration weak. Ringer solution injection increased in 

 rate. 



11.02: Voluntary respiration fairly good. Lid reflex good. Rate of Ringer 

 solution injection is about 20 cubic centimeters per minute. 



11.45: The pinching of the toes causes slight reflex, but no symptoms of 

 convulsions. 



11.47: Injection of Ringer solution stopped. Total quantity injected= 1,300 

 cubic centimeters. 



11.50: Dog is hypersensitive — chloroform increased to 5/12. 



11.55: Hypersensitive — chloroform increased to 6/12. 



11:59: Chloroform reduced to 2/6. 



12.04: Hypersensitive — choloroform increased to 3/6. 



12.07 : Compression of trachea removed. 



12.10: Bog passes 2.5 cubic centimeters of very bloody urine. 



12.26: Chloroform 2/6. Eyes closed. 



12.28: Chloroform turned off. Dog breathes strongly and remains quiet. 



1.10: Fairly strong clonic convulsions begin. They are brief and separated by 

 intervals of only a few seconds during winch the respiration is labored. Noises 

 increase the strength of convulsions or bring them on. The convulsions are not so 

 violent as to demand treatment. 



2.20: Convulsions have practically ceased, 500 cubic centimeters of urine of 

 nearly normal color passed. Respiration about 230 per minute and shallow with 

 frequent short pauses. 



2.26 : Attempts to get onto feet. 



2.40: Still hypersensitive. 



2.45 : Rose on his fore feet and stood' for a time, but then failed in attempt to 

 rise on his hind feet. 



2.47: Rose on all four feet; legs very stiff, mild tetanic dance. 



3.00 : Able to walk fairly well, but staggers ; lack of control is most marked in 

 hind legs. Considerable exophthalmos. 



