﻿118 ASHBUEN AND CRAIG. 



August 3 : At 2 a. m. patient awakened by pain in chest and some difficulty 

 in breathing. This soon passed away and patient slept until morning. Felt 

 well upon awaking this morning but soon developed sharp pain in the head, 

 muscles of the back and legs. Complains also of a slight cough and pain in 

 the eyes. Had slight chill at 5.30 p. m. to-day. No appetite. 



August 4: Patient complains of severe pains in the lumbar region but has no 

 headache. Diarrhoea is present, the stool being watery in character. No appetite. 

 His general appearence is typical of dengue. 



August 5: Still complains of the lumbar pain; at 9 p. m. complained of 

 abdominal pain, accompanied by slight nausea, vomiting and diarrhoea. No 

 eruption has been observed. 



August 6 : Patient feels well. 



August 7 : Patient feels well. 



August 8: Has headache and pain in muscles and joints. Last night was 

 very nervous, almost delirious. Otherwise feels well. 



August 9: Feeling well. Returned to duty August 14, 1906. 



Remarks. — In this case the incubation period, as shown by the accompanying 

 chart, was approximately two days and nineteen hours. The temperature curve 

 is typical of a moderately severe case of dengue and the symptoms corresponded ; 

 the terminal rise and fall is well shown in this chart. No eruption occurred at 

 any time, although otherwise the symptoms were typical, with the exception of 

 the diarrhoea, which was present for a short time, accompanied by nausea and 

 vomiting, which we regard as rather the exception than the rule in dengue. 



Experiment No. 3. 



Case 3, Chart 3. — E. W., private, first class, Hospital Corps, United States 

 Army. At the time of inoculation this man was perfectly well and had not been 

 exposed to dengue. He was given an intravenous inoculation at 2 p. m., August 

 16, of 20 minims of blood from Case 36 (see Chart C). The latter case was 

 typical of dengue, which, at the time the blood was taken had lasted a little 

 over three clays. The clinical record of Case 3 follows : 



August 16: Inoculated with dengue blood at 2 p. m. to-day, the injection being 

 made into a vein of the forearm. 



August 17 and 18: Patient feels well. 



August 19 : Slight temperature last night, but no headache, pain or other 

 symptoms. 



August 20: Last night patient suffered from headache, pain in bones and 

 muscles of back, and severe pain in the knee articulations. Slept poorly. This 

 morning has headache, located in the temporal region, and general muscular 

 pain. Eyeballs are tender to the touch and also pain. Stomach and bowels 

 normal. No appetite. An eruption, which appeared this morning covers almost 

 the entire body, but is especially marked over the trunk and arms; it consists 

 of very fine, slightly elevated papules, dark-red in color, the color disappearing 

 upon pressure. 



August 21: Feels somewhat better this morning. Has pain in eyes, shoulders, 

 wrists and knees. The eruption is still present but is not so vivid in coloring 

 as yesterday. Appetite poor. Bowels regular. Tongue clean and moist. 



August 23: Patient had more headache last night but feels much better this 

 morning. Is having very little pain now. The eruption is still present and the 

 itching is constant. The bowels are loose. Appetite good. 



August 24: Had headache last night which caused insomnia, also aching 

 pain, severe in character, in muscles and joints. The eruption has greatly in- 



