﻿120 ASHBURN AND CRAIG. 



October 3 : At 10 a. m. the patient was given intravenously 20 minims of 

 blood from Case 44 (see Chart E), a very typical case of dengue of about three 

 and one-half days' duration. 



October 4 and 5 : Feels well. 



October 6 : Last night about 10.30 the patient complained of fever and mus- 

 cular pains. This morning has severe pain in head, back and limbs. Face 

 greatly flushed, conjunctivae congested. Bowels constipated. Tongue moist with 

 thin white coating. 



October 7 : Vomited last night. Has less pain this morning, located mostly 

 in the muscles of the loins and thighs. Has considerable headache and pain in 

 the eyes upon movement. Tongue moist and entirely covered with a yellowish 

 coat. Bowels normal. Feels much better but still has muscular pain and 

 headache. 



October 9 : Feeling well. 



October 10 : Had headache and pain last night, but feels well this morning. 



October 15: Returned to duty. 



Remarks. — The temperature curve in this case is one often observed in naturally 

 acquired dengue and the symptoms throughout were typical of the disease. 

 The absence of an eruption is to be noted, not that it is unusual in many natural 

 infections, but because in our experimental cases an eruption was almost always 

 present. Thus of the ten cases in which we were successful beyond doubt in 

 producing dengue, eight presented well marked eruptions, while one was somewhat 

 doubtful in this respect. 



Experiment Wo. 5. 



Case 5, Chart 5. — C. B. D., second-class private, Company B, Engineer Corps, 

 United States Army. This man at the time of volunteering was in good health, 

 but had been exposed to dengue during the Fort William MeKinley epidemic. 

 He was observed for a period of four days before any experiments were made. 

 The following is the clinical record of this case: 



September 19 : At 1 p. m. a small abrasion was made on the mucous membrane 

 of his cheek, and the patient then rinsed his mouth with blood from a dengue 

 case, diluted with salt solution. No results were obtained from this experiment. 



October 4 : Patient slept last night under a mosquito-bar with mosquitoes that 

 had bitten a typical case of dengue the night before. He was bitten several 

 times during the next few nights, but dengue did not develop. 



October 22 : At 3 p. m. to-day an intravenous inoculation of 20 minims of 

 blood from a dengue case (Case 60, Chart F) was given the subject. 



October 23, 24, and 25 : Patient is feeling well. 



October 26 : At 7 p. m. to-day the patient complained of headache, pain in 

 the lumbar region and the legs, and loss of appetite. 



October 27 and 28 : Patient complains of severe headache, pain in the lumbar 

 region and in the joints. His hands and wrists are slightly swollen, and the 

 face, arms and hands greatly flushed. He is constipated and has no appetite. 



October 29: Feeling much better. An eruption has appeared upon the chest 

 and abdomen, resembling more the eruptions due to heat than a dengue eruption. 

 He is still constipated and has but little appetite. 



October 30 and 31: Patient feels well. There is a marked rash over the back 

 and chest which upon the 31st had extended to the arms and legs. This rash 

 is a typical dengue rash. 



November 1 : The rash is still well marked and is present over the entire 

 body, including the palms of the hands and the soles of the feet. 



