﻿122 ASHBURN AND CRAIG. 



Experiment No. 7. 



Case 7, Chart 7. — W. J., private, Troop D, Eighth Cavalry. This ease is of 

 interest because the experimental dengue was complicated by an attack of 

 malarial fever. He had been exposed to dengue at Fort McKinley but was in 

 good health at the time of volunteering. The following is the clinical record of 

 this case: 



September 19 to 26 : Patient was exposed to fomites of dengue during this 

 time in the usual manner. 



September 26: Exposed to mosquitoes that had bitten Case 80 (Chart L) the 

 night before. This case was afterward found to be suffering from astivo-autumnal 

 malaria. 



September 27 to October 8: Patient is feeling well. 



October 8 : Slept last night under a bar with mosquitoes that bit Case 4 

 (Chart 4), and upon the night of the 9th was bitten twice. Dengue did not result 

 from this experiment. 



October 25: Slept last night under a bar with mosquitoes that bit Case 81 

 (Chart M) the night before. Patient states that he did not feel well during 

 the night, and complains of pain in the back of the head and in the lumbar 

 region. 



October 26 to October 28 : Patient is feeling better, sestivo-autumnal malarial 

 parasites were found in his blood on the afternoon of October 27, and quinine at 

 once administered. 



October 30 to November 4 : Patient is feeling well. No further experiments 

 were instituted until November 17. 



November 17: Inoculated at 10.30 a. m. with 20 minims of blood from Case 

 82 (Chart N), who was suffering from a typical attack of dengue, which had 

 lasted about three days. 



November 18 to November 23: Patient feeling well. 



November 24: At 10 a. m. patient had a slight chill, followed by high fever. 

 Upon November 22 an eruption had been noticed covering the entire body, which 

 resembled the eruption of dengue. 



November 26: Patient is feeling well, and is free from pain. He states that 

 he had had considerable pain for several days before his chill. He is covered 

 with an abundant rash which presents all the characteristics observed in our 

 other dengue cases. 



Remarks. — There are several points of interest in this case. Upon September 

 26 he was exposed to the bites of mosquitoes that had bitten a case of astivo- 

 autumnal malaria. Upon October 25 he developed an attack of malarial fever, 

 and the aestivo-autumnal parasites were found in his blood. He denied that he 

 had ever suffered from malaria previously, and while we have been careful to 

 liberate only mosquitoes of the genus Culex fatigans Wied., beneath the bars of 

 the men experimented upon, it may be that an Anopheles may have been present 

 with the mosquitoes liberated. However, as the Anopheles mosquitoes are present 

 here, it is much more probable that the infection occurred from mosquitoes 

 which had bitten a malarial case at some other time. It is difficult in this 

 case to determine just exactly the period of incubation, and the chart is also 

 atypical because of the concurrent malarial infection. However, the clinical 

 symptoms, were A r ery typical, and the presence of the rash removes all doubt as to 

 the nature Of the infection. 



