﻿322 



STRONG. 



infection, but since in testing antirinderpest serum in the laboratory 

 the opportunity presented itself of carrying on these experiments, they 

 will here be recorded. Ten guinea pigs (see Series 66) were inoculated 

 intraperitoneally each with 0.2 cubic centimeter of" virulent rinderpest 

 blood, 0.1 cubic centimeter of which, inoculated on the same day, gave rise 

 to a fatal rinderpest infection in a steer. The guinea pigs showed no 

 unfavorable symptoms following the inoculation. From one to three 

 weeks later the immunity of the animals to plague infection was tested 

 by rubbing a portion of a plague spleen from a guinea pig just dead of 

 pest over a shaved area of the abdomen of the animals to be tested. None 

 of the guinea pigs of the series showed any plague immunity whatever, 

 as may be seen from the table, and all succumbed to acute plague infection. 

 Ten other guinea pigs (Series 67) were each inoculated subcutaneously 

 with 2 cubic centimeters of fresh antirinderpest serum. Six clays later 

 the immunity against plague of the animals was tested by the same 

 method and all died of acute plague infection from the second to the 

 fourth day after inoculation. Therefore, no relationship in immunity 

 between these two infections could be stablished by these experiments, 

 and they gave no encouragement for the performance of similar experi- 

 ments on the larger and more expensive animals, such as cattle. 



Series 66. — Guinea pigs inoculated with virulent rinderpest blood, followed by 



plague infection. 





Inocu- 

 lated 

 Jan- 

 uary 19 

 With 











Ani- 

 mal 

 No. 



vir- 

 ulent 

 rinder- 

 pest 

 blood 

 intra- 

 perito- 

 neally. 



Infeeted by shaving abdomen and rub- 

 bing with — 



Result. 





Remarks. 



1708 



0.2. cc- 



Pest spleen ot guinea pig No. 1702, Jan. 26_ 



Dead Jan. 29, after 

 days. 



3 



Culture from 

 heart, pest 

 bacilli. 



1709 



— do__ 



Pest spleen of guinea pig No. 1703, Jan. 27- 



Dead Feb. 6, after 



L0 



Do. 







days. 







1711 



_._do__ 



Pest spleen of guinea pig No. 1704, Jan. 28_ 



Dead Feb. 4, after 

 days. 



7 



Do. 



1712 



do.. 



Pest spleen of guinea pig No. 1708, Jan.29_ 



Dead Jan. 31, after 



3 



Do. 









days! 







1714 



— do__ 



Pest spleen of guinea pig No. 1712, Jan. 31_ 



Dead Feb. 4, after 

 days. 



4 



Do. 



1724 



___ do__ 



Pest spleen of guinea pig No. 1711, Feb. 4_ 



Dead Feb. 8, after 

 days. 



4 



Do. 



1725 



— do__ 



Pest spleen of guinea pig No 1714, Feb. 4_ 



Dead Feb. 7, after 

 days. 



3 



Do. 



1728 



— do.. 



Pest spleen of guinea pig No. 1709 Feb. 7_ 



Dead Feb. 10, after 

 days. 



3 



Do. 



1729 



-_ao_ 



Pest spleen of guinea pig No. 1725, Feb. 7- 



Dead Feb. 12, after 

 days. 



5 



Do. 



1745 



— do- 



Pest spleen of guinea pig No. 1724, Feb. 8. 



Dead Feb. 12, after 

 days. 



4 



Do. 



