﻿394 MUSGRAVE AND MARSHALL. 



no sharp demarcation between this zone and the necrotic center, and no 

 clear zone of nuclear disintegration except in an early stage, and even 

 then the nuclear fragments are diffused through the whole nodule and 

 there is no karyolysis. Dividing connective tissue nuclei are found in 

 the outer part of this zone, together with numbers of large cells with a 

 single eccentric vesicular nucleus, and fairly abundant protoplasm which 

 takes a bright eosin stain. At the outer margin of the central core, giant 

 cells are occasionally found, with a dozen or more vesicular nuclei placed 

 murally or at the poles of the cell, the protoplasm being abundant, ir- 

 regular in outline and of a bright red color. 



New capillaries and connective tissue cells are abundant between the 

 nodules, the new vessels often being engorged. The nodules contain but 

 few polymorphonuclears. Apparently the nodules are grouped in the 

 neighborhood of a dilated bronchiole. 



There is very little pigment deposited along the lymphatics, but dis- 

 integrated red corpuscles and blood pigment are found near the foci of 

 coagulation necrosis. 



In a section of this blook stained with carbol-fuchsin and methylene 

 blue a small number of slender, acid-fast bacilli are found, often beaded, 

 and occasionally slightly branched. 



Live?-. — Sections of liver stain well ; there is considerable irregular 

 contraction and shrinking of the parenchyma cells, especially around the 

 hepatic veins. The parenchyma cells show no pigment, they are coarsely 

 granular and stain deeply in eosin, and are very irregular in size. There 

 is no evidence of cellular infiltration, and no new connective tissue, even 

 where the shrinkage of parenchyma cells is most marked. 



Spleen. — The section stains well; capillaries are moderately dilated; 

 the contents in many cases have fallen out; the trabecular are somewhat 

 loose and spongy, especially at their margins; the Malpighian bodies are 

 inconspicuous, reduced in size and possibly in number. The sponginess 

 of their reticulum is one factor reducing the prominence of the Malpi- 

 ghian bodies. The bodies contain normal appearing lymphocytes; there 

 is no proliferation. Occasionally, in the center of the Malpighian body, 

 there are found several smaller or larger blocks of bright, red, struc- 

 tureless hyaline material, irregular in size and shape, and apparently free 

 in the tissue. In the neighborhood of such material it is common to 

 find a few of the mononuclears with an increased amount of protoplasm 

 which also has a bright, hyaline-red appearance and which crowds the 

 nucleus to the side. 



A focus is found in the pulp, resembling an encapsulated solitary 

 tubercle, 2.5 millimeters in diameter. The center is composed of a mass 

 of reddish detritus, mostly granular, with a few fragmenting nuclei. 

 At the periphery is a narrow zone of young connective tissue, advancing 

 toward the necrotic center, apparently devoid of vessels. Surrounding 

 this is a narrow zone of concentric lamellae, resembling connective tissue, 



