﻿422 STRONG. 



give rise to the production of amboceptors (immunizing substances) in 

 excess, which may pass off in the exudates from the cells, as for example 

 in the intestinal secretion containing mucus and serum. However, while 

 it is interesting to review this evidence that the organisms in the 

 intestine in Asiatic cholera do, indeed, come into contact with the serum 

 and tissues of the host, the most definite proof that this really takes 

 place is furnished by the fact that after an attack of the disease, both 

 bactericidal and agglutinative substances are produced and may be 

 demonstrated in the blood serum of the individual. It therefore seems 

 to be proved that if cholera organisms should find their way into the 

 intestine of one whose blood serum possesses a high bactericidal power 

 against the spirillum, the individual in question would be in a much more 

 favorable condition for overcoming the infection, or indeed of throwing 

 it off entirety, than if no such bactericidal substances were present. 



Haffkine's extensive statistics demonstrate this fact conclusively and 

 show the value of protective inoculation against this disease, the number 

 of cases of cholera among the inoculated being only about one-tenth 

 that observed in the uninoculated. I have no such extensive statistics 

 to offer in regard to the use of our prophylactic, since we have pursued 

 our inoculations during the past year only in those districts where 

 it was thought that the value of the inoculations might be clearly 

 determined. The first town in which extensive vaccinations were prac- 

 ticed was Angat and its barrios in the Province of Bulacan. The 

 village is situated directly upon a small river from which it derives its 

 entire drinking water supply. Considerable drainage from the town in 

 wet weather passes into this river. Cholera was not present in the 

 town at the time the inoculations were performed, but it had been present 

 there a short time before and it was thought probable that it might 

 recur in that locality during the rainy season. About one-sixth of the 

 population of the village — that is. all who volunteered. 1,078 in number — 

 was injected with the prophylactic. A few months later cholera appeared 

 in the village and 122 persons were stricken with the disease, 121 of 

 whom were among the noninoculated. In the villages of Siniloan. 

 Mabitac. and Malolos, 2,706 persons were inoculated, but since the inocu- 

 lations were performed there has not been sufficient cholera in these 

 localities to draw conclusions of any particular value as to their efficacy. 

 However, only three of the entire number of persons inoculated have 

 contracted the disease. In Bilibid Prison a little over one-half (1.838) 

 of all the inmates was inoculated. During the twelve months following 

 the injections, according to official reports of the Bureau of Health, there 

 have been twenty-four cases of cholera in the prison, only four of 

 which were among the inoculated. 



