38 
1870.] — [Pepper. 
The section of the tooth (Fig. B) showed the existence of numerous ir- 
regularly shaped, branching lacune in the dentine near the marginal 
layer of enamel. These spaces were of various sizes and intercepted the 
Fic. B. 
course of a varying number of dental tubuli. They indicated unquestion- 
ably either an arrest of the process of calcification of the dentine, or of 
the resorption of calcareous matter already deposited, conditions which are 
also present in the true bony tissue. They are identical with the so-called 
interglobular spaces first described by Kolliker and carefully studied by 
Dr. McQuillen of this city, who has published (Dental Cosmos, N. 8. Vol. 
VIII, No. 3, pg. 113,) several excellent illustrations of them. 
PATHOLOGY OF THE DISEASE. 
Having thus described the gross and minute features of these bones, 
we would hazard the following remarks in regard to the nature and cause 
of the pathological process :— 
Tn the first place it is to be observed that three separate processes, or 
at least three distinct stages of the same process, are represented in dif- 
ferent parts of the skeleton, or even, in some instances, in single bones. 
These stages are : 
First. Internal Osteoporosis of the original osseous tissue. 2d. Ex- 
ternal Hyperostosis, due to successive attacks of Periostitis, both of 
which processes are present in varying propertion in almost all the bones, 
and 3d. Secondary Induration. 
A. P. §.—VOL. XII—E 
