22 The Philippine Journal of Science 1913 



This gradual separation of elements of a virus may be cited 

 as an instance of selection, rather than one of either heredi- 

 tary transmission or double virus. To this we reply that a virus 

 offering so wide a field for selection is, in our view, dual and 

 divisible. 



We may here mention that a recent report by Simpson (22) 

 of the apparent simultaneous occurrence of rinderpest and small- 

 pox in an Indian buffalo, taken in connection with the case of 

 Private Vann, to be mentioned later, caused us to think that 

 possibly rinderpest might so weaken the general resistance of 

 cattle as to allow vaccinia to become generalized on them. 



Thanks to the cooperation of the Bureau of Agriculture of 

 these Islands, we have been able to vaccinate 9 Batan or Luzon 

 cattle, either before, at the time of, or shortly after their 

 inoculation with rinderpest. We have obtained localized vac- 

 cinia and rinderpest, but no generalization of vaccinia. With 

 a piece of scab the size of a grain of wheat, taken from the 

 vaccination site of one of these animals, triturated in water, 

 and inoculated into numerous small skin incisions, we have 

 produced good, localized vaccinia and fatal rinderpest in an- 

 other, but no generalization of vaccinia. 



We hope to experiment soon with a buffalo. 



3. CLINICAL OBSERVATIONS ON SMALLPOX 



In 1899 Private Vann of the Twenty-third Infantry was ad- 

 mitted to the military hospital at Cebu, P. I., in a very low 

 state from sprue. Death appeared imminent, and although 

 the man was awaiting transportation to the United States it 

 was feared that he would not live long enough to reach there. 

 Another soldier, suffering from fever, vomiting, headache, and 

 backache was admitted to the ward, and placed in the bed ad- 

 joining Vann's. He died of purpura variolosa in a few days. 

 The condition having been suspected to be variola the day follow- 

 ing the admission, all men in the hospital were at once vacci- 

 nated. Within a time now thought to have been not more 

 than a week (the notes made in 1899 are not available), Vann 

 showed a generalized eruption resembling discrete smallpox. 

 Concomitantly he expressed himself as feeling better and asked 

 for solid food which he ate without discomfort or injury. The 

 improvement begun then continued, and a complete recovery 

 from the sprue followed rapidly. The man was still in the 

 service late in 1911 as a sergeant of the Hospital Corps. 



This case was interpreted at the time and since as one of 

 generalized vaccinia, the generalization occurring because of 



