94 '^he Philippine Journal of Science i9ia 



At the point of greatest infiltration, the intestinal wall was 

 about 1 centimeter in thickness. The lumen of the intestine 

 was not encroached upon but rather enlarged. There were one 

 or two small erosions of the mucosa, and at the thickest portion 

 of the tumor was found a deep ulcer 3 centimeters in diameter 

 with smooth, sloping walls. 



The mesenteric glands were large, firm, and pale, and about 

 them was often found a difi'use infiltration of the mesentery and 

 of the retroperitoneal tissues. The retroperitoneal glands were 

 also enlarged and some were softened. On the anterior surface 

 of the right ventricle of the heart was a small, pale, circular 

 nodule, slightly elevated, measuring about 0.5 centimeter in 

 diameter. There were no metastases in other organs. 



Microscopic examination. — Sections f!'om the thickest part of 

 the intestine showed the tumor to be made up of small groups 

 of cells of lymphoid type, between which were coarse bands of 

 connective tissue, often hyaline, and numerous cells which were 

 evidently of inflammatory origin. In the younger metastatic 

 tumors of the lymphatic glands, the -connective tissue and ad- 

 ventitious cells were much less prominent and only a fine retic- 

 ulum was present. Eosinophilic cells were rather numerous, and 

 multinuclear cells were present, but mitotic figures were rare. 

 Blood vessels were numerous, especially in the metastatic 

 growths. 



The nodule in the heart consisted of a small area not definitely 

 circumscribed, showing diffuse infiltration of the muscle by tu- 

 mor cells with little change in the muscle fibers. Diagnosis: 

 Lymphosarcoma. 



That primary sarcoma of the intestine is infrequent is evi- 

 denced by the statistics of various pathological institutes. Thus 

 Smoler(i) reports that among 13,036 necropsies performed at 

 Prague, in a period of fifteen years, there were but 13 cases, 

 of which 10 were of the small intestine. Corner and Fair- 

 bank (2) in 1904 were able to collect from the literature but 

 65 cases, although, according to Kaufmann,(3) Rademacher(6) 

 reviewed 140 cases in 1908, adding one new one. In our series 

 of 2,200 necropsies, the two given above are the only ones of 

 undoubted primary sarcoma of the intestine. The disease may 

 occur at any age, the youngest case reported being a congenital 

 one and the oldest 70 years of age, although it appears that the 

 greatest number occurs in the fourth decade. In the cases re- 

 ported, the proportion of males to females has been about two 

 to one. 



