VIII, B. 5 Gibson: Salt Mixtures and Beriberi 363 



F'ujii ^° fed 6 monkeys on cooked white rice. Of these, 2 died 

 of simple inanition, 3 of inanition with scorbutic changes, and the 

 sixth in thirty-four days of inanition with symptoms of beriberi. 

 In the sixth monkey the pain sense and patellar reflex were 

 depressed but present during the last days ; the heart was some- 

 what dilated, but not hypertrophied to any great extent; the 

 lungs were congested and oedematous, and there was degeneration 

 of the cells of the anterior horn of the cord and of the peripheral 

 nerves. 



Six recently trapped monkeys of the common Philippine species, 

 Pithecus syrichta (Linnseus), were obtained and placed in 

 separate cages. These were fed on rice which had been boiled 

 until soft in a relatively large amount of distilled water; the rice 

 was washed two or three times, and the water strained off 

 through gauze. To the rice fed to three of the monkeys there 

 was added a salt mixture made up according to the method 

 Osborne and Mendel, except that rice flour was used instead of 

 the lactose, A little banana was added to the rice when cooked 

 to flavor it, as it was found that the monkeys were refusing to 

 eat after the first few days of the experiment. 



On the forty-second day of the experiment, 1 of the salt-fed 

 monkeys, whose weight had fallen from 1,341 to 1,289 grams, 

 became oedematous. The oedema was especially noticeable in 

 the face. On the following day the oedema was more striking. 

 The third day the oedema had largely disappeared* but the 

 monkey was evidently sick, and was irritable when touched. 

 On the forty-sixth day of the experiment, the animal was lying 

 on its side and evidently dying. At necropsy, the body seemed 

 poorly nourished, with the viscera normal except for a slight 

 gastritis. The right heart was greatly dilated, the ventricle 

 wall being very thin. The heart appeared as if double apexed. 

 The lungs seemed normal. There was no excess of fluid in the 

 body cavities, but the tissues seemed wet when cut. Histo- 

 logical examination of the sciatic nerve, as may be seen in the 

 accompanying photomicrograph, showed typical Wallerian de- 

 generation (Plate IV). 



The other 5 monkeys became progressively marasmic. There 

 was no marked difference ih the development of the condi- 

 tions in the salt-rice and the rice groups. One of the monkeys 

 fed on rice alone died on the eighty-sixth day of the experiment. 

 At necropsy the monkey was found to be rough-haired, very 

 poorly nourished and apparently starved, somewhat jaundiced, 



" Verhandlungen der Japanischen Pathologischen Gesellschaft (1912), 39. 



