SOME EXPERIMENTS ON THE INOCULATION OF MONKEYS 

 WITH SMALLPOX 



By P. M. AsHBURN, E. B. Vedder, and E. R. Gentry ' 



(The Uyiited States Army Board for the Study of Tropical Diseases as they 

 Exist in the Philippine Islands) 



Seven charts 



I. EXPERIMENTS WITH VESICLE CONTENTS FROM A CASE OF 

 DISCRETE SMALLPOX 



On December 4 the case of a Dutch traveler who had con- 

 tracted smallpox in China came under observation. This case 

 was a very typical discrete smallpox in a man whose general 

 condition was excellent and who had been successfully vaccinated 

 in childhood (about 1884) and revaccinated with doubtful result 

 about 1900. At the time of admission he was moderately cov- 

 ered with discrete lesions, those on the upper part of the body 

 being good vesicles, those on the feet and legs not quite mature. 

 He was in the eighth day of the disease. Vesicle contents drawn 

 into capillary tubes was used to inoculate 5 monkeys. Other 

 vesicle contents in capillary tubes was preserved for later use. 



Monkey 21. — This animal, an unvaccinated female, was inocu- 

 lated on the belly on December 5. The temperature (101°.4 F. 

 at time of inoculation) rose steadily until the 11th when it 

 reached 104°. 8 F., dropping by the morning of December 12 to 

 95°.4 F. The animal died on the 12th, the cause of death being 

 sepsis from a large abscess below the jaw, which was doubtless 

 due to an injury received in fighting with other monkeys before 

 the inoculation. The sites of inoculation on the belly showed 

 waxy scabs, not to be definitely described as "takes." 



Monkey 5. — A large male monkey, that had been successfully 

 vaccinated in October, was inoculated at 6 sites on the abdomen 

 on December 4 with fresh vesicle contents. No local lesions 

 resulted. There was, however, a moderate rise of temperature 



'P. M. Ashburn, major; E. B. Vedder, captain; and E. R. Gentry, lieu- 

 tenant; Medical Corps, United States Army, member of the United States 

 Ai-my Board for the Study of Tropical Diseases as they Exist in the Phil- 

 ippine Islands. 



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