434 



The Philippine Journal of Science 



liil3 



neither primary nor secondary skin lesions. This fever might 

 well be the manifestation of variola sine eruptione. Placed 

 free on the mucous membranes of the conjunctivae, nares, and 

 mouth, the virus caused no disturbance, or, if any, so little as to 

 be insufficient for interpretation as an evidence of infection. 



Of the fresh vesicle contents tubed and not used on the above 

 monkeys, the greater part, probably 20 tubes, was used for the 

 inoculation, by scarifications and intravenously, of 2 horses. 

 Neither animal showed symptoms or signs that could be inter- 

 preted as smallpox. The remainder, which was partly clear 

 vesicle contents and partly contents drawn on December 7 and 



Date 



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1 



Chart 4. — Temperature chart of monkey 30. 



showing slight turbidity, was kept in an ordinary ice chest for 

 twenty-four days and was then used to inoculate 2 monkeys. 



Monkey 30. — A medium-sized unvaccinated male was inocu- 

 lated at several sites on the abdomen with 24-day-old vesicle 

 contents on December 31. On January 7 an enlargement of a 

 right inguinal lymphatic gland was noted, and on the 8th there 

 was a transient rise of temperature as shown by chart 4. 



Monkey 23. — A large unvaccinated male monkey was inocu- 

 lated December 31 at several points on the abdomen with 24-day- 

 old vesicle contents. On January 6 five points and lines of 

 induration, swelling, and slight redness were noted about inserts, 

 and the temperature was elevated as shown by chart 5. 



