438 "^he Philippine Journal of Science wis 



of temperature on the sixth, seventh, and eighth days, and we 

 are unable to affirm that any infection occurred. 



On January 16 he was again found to be sick and to have a 

 high temperature, and on January 19 he died. Autopsy showed 

 streptococcus septicaemia as the cause of death. That the sharp 

 rises in temperature on December 26 and 28 were related to 

 the septicasmia that caused death three weeks later, notwith- 

 standing the interval of apparent health and normal temperature, 

 is possible. 



Monkey 22. — Inoculated with dry scabs triturated in 0.85 per 

 cent saline solution ; this monkey showed no reaction, either local 

 or general. 



Monkey 26. — Inoculated with glycerinated scabs; this monkey 

 showed no reaction. 



Monkey 27. — Inoculated with glycerinated scabs; showed no 

 reaction. 



Monkey 29. — Inoculated with glycerinated scabs; showed no 

 reaction. 



On December 24 monkeys 12 and 17 were inoculated at 6 

 points on the belly with dried scabs, and monkey 33 with both 

 dry and glycerinated scabs. None of them showed general or 

 local disturbance. 



III. EXPERIMENTS WITH SCABS FROM A CASE OF RECOVERED VARIOLOID 

 ON THE SIXTEENTH DAY 



In addition to the case of smallpox above mentioned, the United 

 States Army transport Shermaii arrived in port on December 1, 

 1912, with a naval recruit in his sixteenth day of modified small- 

 pox, which he had contracted in San Francisco and developed 

 after leaving Honolulu. The attack had been mild, the lesions 

 abortive, and at the time of his arrival here the man showed only 

 a few small, dry, brown scabs. These were all collected, and on 

 December 2 were triturated in sterile 0.8 per cent salt solution 

 and used to inoculate 3 monkeys, Nos. 6, 17, and 18. 



Monkey 6. — This animal had been successfully vaccinated in 

 October. No lesions followed inoculation with the scabs. The 

 animal had an irregular temperature from the first and was 

 sickly. On December 18 it was killed, in order to get vaccine 

 immune serum. 



Monkey 17. — A medium-sized female, unvaccinated, showed no 

 disturbance and no lesions as a result of the inoculation. 



Monkey 18. — A small unvaccinated male showed neither lesions 

 nor systemic disturbance as a result of the inoculation. He was 

 later (December 24) successfully vaccinated. 



